Detailed information of TA system TA206728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 128775..129255
• Replicon: chromosome
• Accession: NZ_CP077093
• Organism: Pseudomonas vanderleydeniana strain RW8P3

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A9E6PL19
• Locus tag: HU752_RS00595
• Protein ID: WP_017902220.1
• Coordinates: 128983..129255 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: HU752_RS00590
• Protein ID: WP_186683714.1
• Coordinates: 128775..128999 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU752_RS00575 (HU752_000575)	125342..126775	+	1434	WP_186683711.1	alanine/glycine:cation symporter family protein	-
HU752_RS00580 (HU752_000580)	127260..127715	+	456	WP_186683712.1	SgcJ/EcaC family oxidoreductase	-
HU752_RS00585 (HU752_000585)	128277..128678	+	402	WP_186683713.1	hypothetical protein	-
HU752_RS00590 (HU752_000590)	128775..128999	+	225	WP_186683714.1	DUF6290 family protein	Antitoxin
HU752_RS00595 (HU752_000595)	128983..129255	+	273	WP_017902220.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU752_RS00600 (HU752_000600)	129336..130328	+	993	WP_186683715.1	AraC family transcriptional regulator	-
HU752_RS00605 (HU752_000605)	130488..131519	+	1032	WP_186683716.1	histone deacetylase family protein	-
HU752_RS00610 (HU752_000610)	131532..132632	+	1101	WP_186683717.1	polyamine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10445.17 Da
• Isoelectric Point: 10.5148

>T206728 WP_017902220.1 NZ_CP077093:128983-129255 [Pseudomonas vanderleydeniana]
MAWRIEFESSAAKELGKLDKQTALRILKFLRERLAALEDPRSIGEALKGSKLGQFWKYRVGDYRIIANIQDEVVSILIVR
VGNRRDVYKH

Nucleotide

• Length: 273 bp

>T206728 NZ_CP102669:c4444214-4443723 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8477.57 Da
• Isoelectric Point: 4.4488

>AT206728 WP_186683714.1 NZ_CP077093:128775-128999 [Pseudomonas vanderleydeniana]
MLAIRLPQDIENRLEALAAATGRTKTFYARQAILEHIDNLEDIYLAEQRLADVRAGRSKTMTLEELEQQYGVED

Nucleotide

• Length: 225 bp

>AT206728 NZ_CP102669:c4444504-4444211 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA