Detailed information of TA system TA206726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 4794882..4795536
• Replicon: chromosome
• Accession: NZ_CP077092
• Organism: Pseudomonas iranensis strain SWRI54

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: HU724_RS21535
• Protein ID: WP_262136717.1
• Coordinates: 4794882..4795229 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: HU724_RS21540
• Protein ID: WP_186567694.1
• Coordinates: 4795219..4795536 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU724_RS21505 (HU724_021505)	4790504..4791490	+	987	WP_186567699.1	hypothetical protein	-
HU724_RS21510 (HU724_021510)	4791538..4792257	-	720	WP_186567698.1	hypothetical protein	-
HU724_RS21515 (HU724_021515)	4792291..4792653	-	363	WP_186567697.1	hypothetical protein	-
HU724_RS21520 (HU724_021520)	4792713..4793528	-	816	WP_186567696.1	sulfite exporter TauE/SafE family protein	-
HU724_RS21525 (HU724_021525)	4793641..4794408	+	768	WP_186567695.1	helix-turn-helix transcriptional regulator	-
HU724_RS21530 (HU724_021530)	4794502..4794819	+	318	WP_056788034.1	hypothetical protein	-
HU724_RS21535 (HU724_021535)	4794882..4795229	+	348	WP_262136717.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU724_RS21540 (HU724_021540)	4795219..4795536	+	318	WP_186567694.1	helix-turn-helix transcriptional regulator	Antitoxin
HU724_RS21545 (HU724_021545)	4795547..4796602	-	1056	WP_130887349.1	MBL fold metallo-hydrolase	-
HU724_RS21550 (HU724_021550)	4796814..4797422	+	609	WP_016773570.1	TetR/AcrR family transcriptional regulator	-
HU724_RS21555 (HU724_021555)	4797655..4798974	+	1320	WP_186567693.1	PAS domain-containing methyl-accepting chemotaxis protein	-
HU724_RS21560 (HU724_021560)	4799074..4799778	+	705	WP_186567692.1	CTP synthase	-
HU724_RS21565 (HU724_021565)	4799926..4800252	-	327	WP_133339664.1	DUF2025 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (8-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-84)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12780.53 Da
• Isoelectric Point: 7.7984

>T206726 WP_262136717.1 NZ_CP077092:4794882-4795229 [Pseudomonas iranensis]
MWVCSSKKDLKQMPTEVQDVFGHALDLAQCGLKYSDAKPLKGFGGAGVLELIEDFDTDTYRAIYTVRFGSAIYVLHCFQK
KSKSGIKTAQSDIDLIRNRLRAAQEHAKGSENHGD

Nucleotide

• Length: 348 bp

>T206726 NZ_CP102669:c4221412-4221125 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11576.54 Da
• Isoelectric Point: 10.1491

>AT206726 WP_186567694.1 NZ_CP077092:4795219-4795536 [Pseudomonas iranensis]
MEIEVGSGNVYHDLDLPNASEMQVKSQLAAKIGAIIKARHLTQVQASEILGLSQPKLSEMLRGKFRGISEAKMMECLSRL
GRDVQIVVKSAPRSRKEGRIEVVFA

Nucleotide

• Length: 318 bp

>AT206726 NZ_CP102669:c4221138-4220836 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG