206724

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2902985..2903504 Replicon chromosome
Accession NZ_CP077092
Organism Pseudomonas iranensis strain SWRI54

Toxin (Protein)


Gene name relE Uniprot ID A0A142NAM9
Locus tag HU724_RS13000 Protein ID WP_039758603.1
Coordinates 2903223..2903504 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1N6YEG7
Locus tag HU724_RS12995 Protein ID WP_039758605.1
Coordinates 2902985..2903233 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU724_RS12975 (HU724_012975) 2898468..2899160 + 693 WP_189691387.1 VWA domain-containing protein -
HU724_RS12980 (HU724_012980) 2899518..2901077 + 1560 WP_186567171.1 TerC family protein -
HU724_RS12985 (HU724_012985) 2901113..2902189 - 1077 WP_186567169.1 GGDEF domain-containing protein -
HU724_RS12990 (HU724_012990) 2902305..2902736 - 432 WP_186567167.1 thioredoxin family protein -
HU724_RS12995 (HU724_012995) 2902985..2903233 + 249 WP_039758605.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HU724_RS13000 (HU724_013000) 2903223..2903504 + 282 WP_039758603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU724_RS13005 (HU724_013005) 2903786..2904634 + 849 WP_186567165.1 transporter substrate-binding domain-containing protein -
HU724_RS13010 (HU724_013010) 2904685..2905347 + 663 WP_024012746.1 amino acid ABC transporter permease -
HU724_RS13015 (HU724_013015) 2905357..2906019 + 663 WP_186567163.1 amino acid ABC transporter permease -
HU724_RS13020 (HU724_013020) 2906016..2906807 + 792 WP_130911292.1 amino acid ABC transporter ATP-binding protein -
HU724_RS13025 (HU724_013025) 2906839..2907228 + 390 WP_186567161.1 RidA family protein -
HU724_RS13030 (HU724_013030) 2907387..2908151 + 765 WP_186567233.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10876.71 Da        Isoelectric Point: 10.8793

>T206724 WP_039758603.1 NZ_CP077092:2903223-2903504 [Pseudomonas iranensis]
MTYELEFSEKAWKEWRKLGSELREQFKNKLVERLANPHVPAARLKGLSNAYKIKLRSAGYRLVYRVRDEVLVVTVIAVGK
RQGGDVYRQALKR

Download         Length: 282 bp

>T206724 NZ_CP102669:3620585-3620803 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9043.47 Da        Isoelectric Point: 4.7905

>AT206724 WP_039758605.1 NZ_CP077092:2902985-2903233 [Pseudomonas iranensis]
MTHIVLSHVVASISELKKNPMGTVAAGGGRSVAILNRNEPAFYCVPAKEYEAMMERLEDLELIALCKERENDPTIKVSID
DL

Download         Length: 249 bp

>AT206724 NZ_CP102669:3620183-3620557 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142NAM9

Antitoxin

Source ID Structure
AlphaFold DB A0A1N6YEG7

References