206722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1940146..1940762 Replicon chromosome
Accession NZ_CP077092
Organism Pseudomonas iranensis strain SWRI54

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HU724_RS08620 Protein ID WP_186565952.1
Coordinates 1940146..1940358 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HU724_RS08625 Protein ID WP_186565950.1
Coordinates 1940358..1940762 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU724_RS08595 (HU724_008595) 1935385..1937373 + 1989 WP_186565959.1 heme lyase CcmF/NrfE family subunit -
HU724_RS08600 (HU724_008600) 1937370..1937906 + 537 WP_016771042.1 DsbE family thiol:disulfide interchange protein -
HU724_RS08605 (HU724_008605) 1937903..1938373 + 471 WP_016771041.1 cytochrome c-type biogenesis protein CcmH -
HU724_RS08610 (HU724_008610) 1938370..1939569 + 1200 WP_186565956.1 c-type cytochrome biogenesis protein CcmI -
HU724_RS08615 (HU724_008615) 1939595..1939999 + 405 WP_186565954.1 hypothetical protein -
HU724_RS08620 (HU724_008620) 1940146..1940358 + 213 WP_186565952.1 type II toxin-antitoxin system HicA family toxin Toxin
HU724_RS08625 (HU724_008625) 1940358..1940762 + 405 WP_186565950.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HU724_RS08630 (HU724_008630) 1940875..1942074 - 1200 WP_186565948.1 MFS transporter -
HU724_RS08635 (HU724_008635) 1942243..1943241 - 999 WP_016771033.1 sulfate ABC transporter substrate-binding protein -
HU724_RS08640 (HU724_008640) 1943345..1944169 - 825 WP_186565946.1 ion transporter -
HU724_RS08645 (HU724_008645) 1944191..1945105 - 915 WP_186565944.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7992.08 Da        Isoelectric Point: 10.0855

>T206722 WP_186565952.1 NZ_CP077092:1940146-1940358 [Pseudomonas iranensis]
VQSRLLMNELEEADWTLDRVAGSHHIFTHRYNPNTIAVPHPKKDLPLATVKSIRRRAGLFSPPTRHEGDP

Download         Length: 213 bp

>T206722 NZ_CP102669:2170067-2170170 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14794.91 Da        Isoelectric Point: 4.8944

>AT206722 WP_186565950.1 NZ_CP077092:1940358-1940762 [Pseudomonas iranensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEEAYNAAVEVAHLMLQEIAAAGQAIPMPTSAAAHRNRPDFAKMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT206722 NZ_CP102669:c2170172-2170027 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References