Detailed information of TA system TA206721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1103341..1103930
• Replicon: chromosome
• Accession: NZ_CP077092
• Organism: Pseudomonas iranensis strain SWRI54

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU724_RS04830
• Protein ID: WP_081489836.1
• Coordinates: 1103679..1103930 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: V8R847
• Locus tag: HU724_RS04825
• Protein ID: WP_016771749.1
• Coordinates: 1103341..1103682 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU724_RS04800 (HU724_004800)	1098910..1099311	+	402	WP_016771753.1	30S ribosome-binding factor RbfA	-
HU724_RS04805 (HU724_004805)	1099316..1100233	+	918	WP_024011571.1	tRNA pseudouridine(55) synthase TruB	-
HU724_RS04810 (HU724_004810)	1100377..1100646	+	270	WP_016771751.1	30S ribosomal protein S15	-
HU724_RS04815 (HU724_004815)	1100851..1102956	+	2106	WP_024011572.1	polyribonucleotide nucleotidyltransferase	-
HU724_RS04825 (HU724_004825)	1103341..1103682	-	342	WP_016771749.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU724_RS04830 (HU724_004830)	1103679..1103930	-	252	WP_081489836.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU724_RS04835 (HU724_004835)	1104286..1104585	+	300	WP_186568030.1	DUF6388 family protein	-
HU724_RS04840 (HU724_004840)	1104687..1105535	-	849	WP_016771747.1	carboxylating nicotinate-nucleotide diphosphorylase	-
HU724_RS04845 (HU724_004845)	1105802..1107979	+	2178	WP_186568032.1	DUF1631 domain-containing protein	-
HU724_RS04850 (HU724_004850)	1108044..1108604	+	561	WP_125927175.1	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9174.63 Da
• Isoelectric Point: 10.7459

>T206721 WP_081489836.1 NZ_CP077092:c1103930-1103679 [Pseudomonas iranensis]
MSKTEKLLAKLVNGRSAFTWSELVTLLARLGYSQLEGSGSRIKFDNGNPSALINLHKPHPGNEIKTYARRQIIEQLKTGG
LIP

Nucleotide

• Length: 252 bp

>T206721 NZ_CP102669:c990863-990336 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12594.21 Da
• Isoelectric Point: 5.9655

>AT206721 WP_016771749.1 NZ_CP077092:c1103682-1103341 [Pseudomonas iranensis]
MSSQLHYKGYVGSIEASTEDKCLFGKLLFIRALVNYEGQTVAELEAAFREAVDDYLQTCEQLGQKPEIPCKGSFNVRIGH
DLHLAAALAATRQNVSLNDLTRQALNEYLQHHA

Nucleotide

• Length: 342 bp

>AT206721 NZ_CP102669:c991150-990860 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: V8R847