206719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 692943..693574 Replicon chromosome
Accession NZ_CP077092
Organism Pseudomonas iranensis strain SWRI54

Toxin (Protein)


Gene name mazF Uniprot ID A0A1N7CQ04
Locus tag HU724_RS03115 Protein ID WP_041477600.1
Coordinates 693212..693574 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J2YH56
Locus tag HU724_RS03110 Protein ID WP_008077592.1
Coordinates 692943..693212 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU724_RS03075 (HU724_003075) 688443..688988 - 546 WP_186567490.1 hypothetical protein -
HU724_RS03080 (HU724_003080) 688985..689239 - 255 WP_016772026.1 acyl carrier protein -
HU724_RS03085 (HU724_003085) 689249..689524 - 276 WP_039756723.1 phosphopantetheine-binding protein -
HU724_RS03090 (HU724_003090) 689502..690314 - 813 WP_186567488.1 lysophospholipid acyltransferase family protein -
HU724_RS03095 (HU724_003095) 690290..691015 - 726 WP_016772023.1 beta-ketoacyl synthase chain length factor -
HU724_RS03100 (HU724_003100) 691372..692142 + 771 WP_186567486.1 ParA family protein -
HU724_RS03105 (HU724_003105) 692273..692707 - 435 WP_186567483.1 thioredoxin TrxC -
HU724_RS03110 (HU724_003110) 692943..693212 + 270 WP_008077592.1 hypothetical protein Antitoxin
HU724_RS03115 (HU724_003115) 693212..693574 + 363 WP_041477600.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HU724_RS03120 (HU724_003120) 693580..695043 - 1464 WP_186567481.1 YdiU family protein -
HU724_RS03125 (HU724_003125) 695092..698445 - 3354 WP_024011301.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13337.24 Da        Isoelectric Point: 7.1674

>T206719 WP_041477600.1 NZ_CP077092:693212-693574 [Pseudomonas iranensis]
MVRRQPPQRGDVYWIDPNPVAGREMMNRHRFVVITPREINALGVSMTVPVTSGGNFSRNMGLAVAITGHETNGVAVCNQV
RSFDIEQRVRDGTAKFIERLDDVTMSDIVDRVISAIDPLS

Download         Length: 363 bp

>T206719 NZ_CP102669:833159-833572 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9521.94 Da        Isoelectric Point: 5.1069

>AT206719 WP_008077592.1 NZ_CP077092:692943-693212 [Pseudomonas iranensis]
MSVTSKIRRQGGAAVITIPPTLLKLLHLEVGAQLELNVVDGELIARPAVAATRKRYSLSELLEGAEELQKLNAQTSETLE
GDSVGRELG

Download         Length: 270 bp

>AT206719 NZ_CP102669:832912-833178 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1N7CQ04

Antitoxin

Source ID Structure
AlphaFold DB J2YH56

References