206718

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 543829..544457 Replicon chromosome
Accession NZ_CP077092
Organism Pseudomonas iranensis strain SWRI54

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HU724_RS02435 Protein ID WP_016772140.1
Coordinates 543829..544227 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HU724_RS02440 Protein ID WP_186568587.1
Coordinates 544227..544457 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU724_RS02415 (HU724_002415) 539504..540199 - 696 WP_016772144.1 ABC transporter permease -
HU724_RS02420 (HU724_002420) 540277..541029 - 753 WP_186568585.1 ABC transporter substrate-binding protein -
HU724_RS02425 (HU724_002425) 541043..541816 - 774 WP_024011209.1 ABC transporter ATP-binding protein -
HU724_RS02430 (HU724_002430) 542359..543750 + 1392 WP_016772141.1 GABA permease -
HU724_RS02435 (HU724_002435) 543829..544227 - 399 WP_016772140.1 tRNA(fMet)-specific endonuclease VapC Toxin
HU724_RS02440 (HU724_002440) 544227..544457 - 231 WP_186568587.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HU724_RS02445 (HU724_002445) 544623..545075 - 453 WP_016772138.1 hypothetical protein -
HU724_RS02450 (HU724_002450) 545082..545495 - 414 WP_016772137.1 hypothetical protein -
HU724_RS02455 (HU724_002455) 545525..546445 - 921 WP_225927657.1 alpha/beta fold hydrolase -
HU724_RS02460 (HU724_002460) 546567..547625 - 1059 WP_186568648.1 PDDEXK nuclease domain-containing protein -
HU724_RS02465 (HU724_002465) 547905..548249 - 345 WP_186568591.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 534356..552789 18433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14547.92 Da        Isoelectric Point: 7.1340

>T206718 WP_016772140.1 NZ_CP077092:c544227-543829 [Pseudomonas iranensis]
MIKYMLDTNICIFTIKNKPQIVREAFNRHSGQLCISAITLMELIYGAEKSAAPEKNLAIVEGFVARLDVLPFDNDAAAQA
GMVRSELAKAGTPIGPYDQMIAGHARSLGLIVVTNNVREFQRVSGLRIEDWV

Download         Length: 399 bp

>T206718 NZ_CP102669:364853-365128 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8574.60 Da        Isoelectric Point: 4.5045

>AT206718 WP_186568587.1 NZ_CP077092:c544457-544227 [Pseudomonas iranensis]
MEQTTIFMSNRSQAVRLPKAVAMPGDVKRVEVIAIGRTRVITPAGESWDSWFDGDSVSPDFMANREQPTDQERESF

Download         Length: 231 bp

>AT206718 NZ_CP102669:364590-364850 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References