Detailed information of TA system TA206717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 484121..484764
• Replicon: chromosome
• Accession: NZ_CP077092
• Organism: Pseudomonas iranensis strain SWRI54

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU724_RS02130
• Protein ID: WP_110644779.1
• Coordinates: 484121..484303 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A4Q4LAA7
• Locus tag: HU724_RS02135
• Protein ID: WP_039756416.1
• Coordinates: 484363..484764 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU724_RS02115 (HU724_002115)	479416..480408	-	993	WP_186568531.1	D-cysteine desulfhydrase	-
HU724_RS02120 (HU724_002120)	480600..481526	+	927	WP_186568533.1	serine acetyltransferase	-
HU724_RS02125 (HU724_002125)	481920..483881	+	1962	WP_186568641.1	choline transporter BetT	-
HU724_RS02130 (HU724_002130)	484121..484303	+	183	WP_110644779.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU724_RS02135 (HU724_002135)	484363..484764	+	402	WP_039756416.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU724_RS02140 (HU724_002140)	484803..484925	-	123	Protein_421	LacI family transcriptional regulator	-
HU724_RS02145 (HU724_002145)	485288..486325	+	1038	WP_016772192.1	L-glyceraldehyde 3-phosphate reductase	-
HU724_RS02150 (HU724_002150)	486526..487368	-	843	WP_186568535.1	taurine dioxygenase	-
HU724_RS02155 (HU724_002155)	487512..488345	-	834	WP_186568537.1	taurine ABC transporter permease TauC	-
HU724_RS02160 (HU724_002160)	488342..489136	-	795	WP_186568539.1	taurine ABC transporter ATP-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6934.03 Da
• Isoelectric Point: 10.5417

>T206717 WP_110644779.1 NZ_CP077092:484121-484303 [Pseudomonas iranensis]
MRSREMIRMIEDDGWYLVAVKGSHHQYKHSFKQGRVTIKHPDSDLPKGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T206717 NZ_CP102669:316716-317084 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14652.46 Da
• Isoelectric Point: 4.5860

>AT206717 WP_039756416.1 NZ_CP077092:484363-484764 [Pseudomonas iranensis]
MKFPVVLHKDADSDYGVIIPDVPGCYSAGATVAEAFENTQEALALHYEGLVADGAPLPQVRDIDAHLDNPDYAGGIWGVV
DFDITPYFGKSVRFNATLPEQLLERIDQTVRRDRRYRSRSGFLAAAALRELSV

Nucleotide

• Length: 402 bp

>AT206717 NZ_CP102669:316498-316719 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A4Q4LAA7