Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 137669..139293 | Replicon | chromosome |
| Accession | NZ_CP077092 | ||
| Organism | Pseudomonas iranensis strain SWRI54 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | HU724_RS00650 | Protein ID | WP_186568770.1 |
| Coordinates | 137944..139293 (-) | Length | 450 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | V8R249 |
| Locus tag | HU724_RS00645 | Protein ID | WP_024014849.1 |
| Coordinates | 137669..137947 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HU724_RS00615 (HU724_000615) | 133110..133733 | + | 624 | WP_186568773.1 | FMN-binding negative transcriptional regulator | - |
| HU724_RS00620 (HU724_000620) | 133744..134190 | + | 447 | WP_137214449.1 | GNAT family N-acetyltransferase | - |
| HU724_RS00625 (HU724_000625) | 134203..134874 | + | 672 | WP_186568772.1 | GNAT family protein | - |
| HU724_RS00630 (HU724_000630) | 134995..135897 | - | 903 | WP_186568771.1 | homocysteine S-methyltransferase family protein | - |
| HU724_RS00635 (HU724_000635) | 136010..136828 | + | 819 | WP_016772458.1 | ABC transporter substrate-binding protein | - |
| HU724_RS00640 (HU724_000640) | 136825..137661 | + | 837 | WP_016772457.1 | amino acid ABC transporter permease | - |
| HU724_RS00645 (HU724_000645) | 137669..137947 | - | 279 | WP_024014849.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HU724_RS00650 (HU724_000650) | 137944..139293 | - | 1350 | WP_186568770.1 | HipA domain-containing protein | Toxin |
| HU724_RS00655 (HU724_000655) | 139653..141860 | + | 2208 | WP_186568769.1 | autotransporter outer membrane beta-barrel domain-containing protein | - |
| HU724_RS00660 (HU724_000660) | 142070..143878 | - | 1809 | WP_186568768.1 | sodium-extruding oxaloacetate decarboxylase subunit alpha | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 49961.60 Da Isoelectric Point: 5.1645
>T206716 WP_186568770.1 NZ_CP077092:c139293-137944 [Pseudomonas iranensis]
MYELTLQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEAGYLVENIESIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPVEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLEVIRMLAGLWRKAGQASQIPVLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPRELERAGDVDWRGVCRVLADSADPHDSLARLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ
MYELTLQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEAGYLVENIESIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPVEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVISRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLEVIRMLAGLWRKAGQASQIPVLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPRELERAGDVDWRGVCRVLADSADPHDSLARLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ
Download Length: 1350 bp
>T206716 NZ_CP102669:206806-207291 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 93 a.a. Molecular weight: 10318.09 Da Isoelectric Point: 10.7364
>AT206716 WP_024014849.1 NZ_CP077092:c137947-137669 [Pseudomonas iranensis]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTV
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTV
Download Length: 279 bp
>AT206716 NZ_CP102669:206531-206818 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|