Detailed information of TA system TA206715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 5845395..5845920
• Replicon: chromosome
• Accession: NZ_CP077091
• Organism: Pseudomonas hamedanensis strain SWRI65

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HU739_RS25665
• Protein ID: WP_186546767.1
• Coordinates: 5845624..5845920 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6I4K355
• Locus tag: HU739_RS25660
• Protein ID: WP_039761862.1
• Coordinates: 5845395..5845634 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU739_RS25635 (HU739_025635)	5841188..5841649	+	462	WP_003228592.1	GNAT family N-acetyltransferase	-
HU739_RS25640 (HU739_025640)	5841882..5842532	+	651	WP_016773001.1	DedA family protein	-
HU739_RS25645 (HU739_025645)	5842537..5843349	+	813	WP_186546769.1	zinc-dependent peptidase	-
HU739_RS25650 (HU739_025650)	5843462..5843989	+	528	WP_003205933.1	inorganic diphosphatase	-
HU739_RS25655 (HU739_025655)	5844206..5844952	+	747	WP_186546768.1	helix-turn-helix transcriptional regulator	-
HU739_RS25660 (HU739_025660)	5845395..5845634	+	240	WP_039761862.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HU739_RS25665 (HU739_025665)	5845624..5845920	+	297	WP_186546767.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU739_RS25670 (HU739_025670)	5845991..5846074	+	84	Protein_5088	DUF4433 domain-containing protein	-
HU739_RS25675 (HU739_025675)	5846071..5847156	+	1086	WP_186546766.1	macro domain-containing protein	-
HU739_RS25680 (HU739_025680)	5847202..5848014	-	813	WP_186546765.1	DUF2135 domain-containing protein	-
HU739_RS25685 (HU739_025685)	5848018..5849637	-	1620	WP_186546764.1	DUF2300 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11628.47 Da
• Isoelectric Point: 9.6903

>T206715 WP_186546767.1 NZ_CP077091:5845624-5845920 [Pseudomonas hamedanensis]
MTYELEFDRRALKEWNKLGDTVRQQFKKKLAEVLENPRIEANRLRELPDCYKVKLKSAGYRLIYQVLDQEILVFVVAIGK
REREAAYEVAQDRLPSRA

Nucleotide

• Length: 297 bp

>T206715 NZ_CP102668:c104174-102900 [Sphingobium sp. JS3065]
ATGACCGCCGACATTCTTGAGCGGCTTGTCGTTTGGTCGGATCAGCGGATCGCCGGTGAACTTTCCATCGACCGGGGCGG
CGCGATGCATTTCATCTATGCCGACGATTGGCTGGCCGATCCAGCGGCAGGCCCGCTTTCGCACGCGCTTCCCAAGCAAG
CAGAGCCATTCGGCGATGCGTTATGTAAGGCCGTCTTTGGTGGACTCCTGCCCGAAGAGGGGCAGCGAACAGCCATCGCG
CGGGCGCTCGGTGTATCGCCTGACAACCCCTTTCGATTGTTGGCTGCGCTCGGCGGTGATGTTGCAGGCGCGCTCGCCTT
TCTGCCCGAAGGGGAGAAACCGCCGCTGCCCCCTGAAGGTGAGCCGCCCCCTGCGCTGGATGATGCTGAGCTCGCGGTTT
TGATCGGTCGCCTGCCGCGCGTACCGATGCTGGCCGGGGAAGGGGGCGCACGACTCAGCTTGGCTGGCGCCCAGGGCAAG
CTCCCCGTCGTGCTTGCCGAGGGGCGGGTAGCCGTGCCGCGCGTAGGTGAGCCATCTACGCACCTCATCAAGCCGGAGCC
CGATCGCTTTCCCGGCCTTGCCGCCAATGAAGCCTTCTGCCTGGCACTGGCGCGCGCAGTGGGTCTCGATGCTGCCATGG
CAGAGTGGCGAGAGGTCGCTGATAAACCCTATTTGCTGGTCACTCGCTACGATCGTCTGGATCGCGAGGGCCATACGATC
CGGTTGCATCAGGAGGATTTTGCGCAGGCGCAGGGCGTACCGTCCAACCGCAAATATGCCAGCGAAGGCGGGCCAACCTT
CCGCGATTGCTTCGCGTTGGTGCGCCAGGCGACCACCCGGCCGGCACGCGAGGTGCTGAAGCTCGCCGACGCGGCAATCT
TCAATGCGATCATCGGCAACGCTGACGCCCATGCGAAGAATTACAGCCTCCTTCGCCAGAGCAAGGGCGAGGTCGTGCTC
GCACCGCTGTACGATCTGGTTGCAACCCACATGTGGCCAGAGCTGTCAGCGAAGCTCGCCATGCGTTTCGGCCGTGCCGC
TACGCTGGAGGAAATAGATGCCGGAAGCTTTGAGCGCTTTGCTGGCGATACGGGATTGGCTCTACCGTTTCTTCGCCGCC
GCGTGGCGGCGCTCGCAGCCCGGGTCCAAGAAGTCATTTCAGGTGGCGTCACCGTGCGAGGGTTAGATGACAGCGCCTGC
CTCGGTGAACTCCCGTCAATTGTCCTCGACCGTGCTGCTCGGTTGGCACTGAAGGCACAGTCGCTGGCTTATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8853.19 Da
• Isoelectric Point: 4.6017

>AT206715 WP_039761862.1 NZ_CP077091:5845395-5845634 [Pseudomonas hamedanensis]
MASINIRIDDDLKQRSFAELEKLGVTPSELLRQTLQYVAERGKLPFKAALLSEEDEALIAVVTERLASPQRVKVSLDDL

Nucleotide

• Length: 240 bp

>AT206715 NZ_CP102668:c104404-104171 [Sphingobium sp. JS3065]
ATGCTCGATATGACGATGATCGGCCAGATTGTTCGAGACGAGCGAAAGGAAATGGGGCTGCGCCAGGACGAATTGGCGGC
TGCCAGCGGAGTGGGCTTGCGCTTCATCGTTGAACTTGAGCGCGGCAAGGCAACGGCACAGATTGGCAAGGTTATTACGG
TTCTTGCGGCTTTAGGCTGCGAGCTTCAGATCCGTCGTCCCGACGGGATCGTGATCGCGGGACAGCCAACATGA

Structures

Antitoxin

• AlphaFold DB: A0A6I4K355