Detailed information of TA system TA206714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 5083123..5083798
• Replicon: chromosome
• Accession: NZ_CP077091
• Organism: Pseudomonas hamedanensis strain SWRI65

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: HU739_RS22190
• Protein ID: WP_186551475.1
• Coordinates: 5083123..5083491 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: HU739_RS22195
• Protein ID: WP_186551476.1
• Coordinates: 5083481..5083798 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU739_RS22160 (HU739_022160)	5078514..5079704	-	1191	WP_186551469.1	hypothetical protein	-
HU739_RS22165 (HU739_022165)	5079816..5080508	-	693	WP_186551470.1	hypothetical protein	-
HU739_RS22170 (HU739_022170)	5080542..5080904	-	363	WP_186551471.1	hypothetical protein	-
HU739_RS22175 (HU739_022175)	5080974..5081789	-	816	WP_186551472.1	sulfite exporter TauE/SafE family protein	-
HU739_RS22180 (HU739_022180)	5081901..5082668	+	768	WP_186551473.1	helix-turn-helix transcriptional regulator	-
HU739_RS22185 (HU739_022185)	5082762..5083079	+	318	WP_186551474.1	XRE family transcriptional regulator	-
HU739_RS22190 (HU739_022190)	5083123..5083491	+	369	WP_186551475.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU739_RS22195 (HU739_022195)	5083481..5083798	+	318	WP_186551476.1	helix-turn-helix transcriptional regulator	Antitoxin
HU739_RS22200 (HU739_022200)	5083809..5084864	-	1056	WP_186551477.1	MBL fold metallo-hydrolase	-
HU739_RS22205 (HU739_022205)	5085078..5085686	+	609	WP_186551478.1	TetR/AcrR family transcriptional regulator	-
HU739_RS22210 (HU739_022210)	5085929..5087248	+	1320	WP_186551479.1	PAS domain-containing methyl-accepting chemotaxis protein	-
HU739_RS22215 (HU739_022215)	5087400..5088332	-	933	WP_186551480.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (15-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-84)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13557.51 Da
• Isoelectric Point: 9.1644

>T206714 WP_186551475.1 NZ_CP077091:5083123-5083491 [Pseudomonas hamedanensis]
MSARKPLLWVCSSKKDLKQMPTEVQDVFGHALDLAQCGLRFSDAKPLKGFGGAGVLELIEDFDTDTYRAIYTVRFGSAIY
VLHCFQKKSKSGIKTAQSDIDLIRNRLRAAQEHAKGSENHGN

Nucleotide

• Length: 369 bp

>T206714 NZ_CP102665:c940809-940516 [Sphingobium sp. JS3065]
ATGGCTGAAATCATCATCTCGCAGCAGGCGGATGACGATTTTGAACGAATCTGGCTCAACATCGCGCTCGACAACGACGA
TGCCGCCGATCGCCTGTTGCGCGCCATAAACGTCAAGATAGAGCGCCTTCGCATCTTCCCGGAAATCGGGCGCGCGCGCG
ACGATCTCAGCCCAGGCGCGCGAGGGCTGGTCCACGGCTCCTACCTGATCCTCTATGAATATGATGCGGCGCGCGACGTG
GTTACGATAGTTACCGTGGTCGAGGGGATGCGCGATCTGGATTGCCTATTCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11595.59 Da
• Isoelectric Point: 10.1490

>AT206714 WP_186551476.1 NZ_CP077091:5083481-5083798 [Pseudomonas hamedanensis]
MEIEVGSANVYQDLDLPNASEMQVKSQLAAKIGAIIKARHLTQIQASEILGLSQPKLSEMLRGKFRGISEAKMMECLSRL
GRDVQIVVKSAPRSRKEGRIEVVFA

Nucleotide

• Length: 318 bp

>AT206714 NZ_CP102665:c941062-940802 [Sphingobium sp. JS3065]
ATGACCGTCGTGGTCCCCGATCAGATGGCCGCGAAAATTCATGCCGCCGTCGAGGCTGGTGAATATGCCTCTGCCAGCGA
AGTCGTGCGCGATGCAATGCGGCTGTGGAGCGAGCGGCGCGAGTTCCGCCAGGACGAATTGCTGGCGCTGCGTGAGGCGT
GGGATCGTGGCAAGGCCAGCGGTGTCGCGGGCCCACTCGACATGGAAGCCATCATCTCGCGAGCGAAGGGCAAGAAGGCA
GCTGCATCCGGCAATGGCTGA