Detailed information of TA system TA206711

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HTH_37(antitoxin)
• Location: 3733173..3733812
• Replicon: chromosome
• Accession: NZ_CP077091
• Organism: Pseudomonas hamedanensis strain SWRI65

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU739_RS16135
• Protein ID: WP_186548487.1
• Coordinates: 3733630..3733812 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HU739_RS16130
• Protein ID: WP_186548485.1
• Coordinates: 3733173..3733598 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU739_RS16115 (HU739_016115)	3728910..3731048	-	2139	WP_186548481.1	ATP-dependent endonuclease	-
HU739_RS16120 (HU739_016120)	3731773..3732273	-	501	WP_225922739.1	transcriptional regulator	-
HU739_RS16125 (HU739_016125)	3732299..3732652	-	354	WP_186548483.1	type II toxin-antitoxin system HigB family toxin	-
HU739_RS16130 (HU739_016130)	3733173..3733598	-	426	WP_186548485.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU739_RS16135 (HU739_016135)	3733630..3733812	-	183	WP_186548487.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU739_RS16140 (HU739_016140)	3734283..3734564	+	282	WP_186548489.1	DUF3077 domain-containing protein	-
HU739_RS16145 (HU739_016145)	3734609..3735289	-	681	WP_225922740.1	RES family NAD+ phosphorylase	-
HU739_RS16150 (HU739_016150)	3735286..3735693	-	408	WP_186548491.1	MbcA/ParS/Xre antitoxin family protein	-
HU739_RS16155 (HU739_016155)	3736014..3736940	+	927	WP_186548493.1	LysR family transcriptional regulator	-
HU739_RS16160 (HU739_016160)	3736857..3737174	-	318	WP_024011198.1	AzlD domain-containing protein	-
HU739_RS16165 (HU739_016165)	3737153..3737869	-	717	WP_186548495.1	AzlC family ABC transporter permease	-
HU739_RS16170 (HU739_016170)	3737866..3738243	-	378	WP_186548705.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3714324..3734564	20240

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-56)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6769.85 Da
• Isoelectric Point: 10.7304

>T206711 WP_186548487.1 NZ_CP077091:c3733812-3733630 [Pseudomonas hamedanensis]
MKYSEFRRWLKAQGVEFQAGKGSHFKVSLSGKSTVFPDHGAKEMGEGLRKTIIKQLSLKD

Nucleotide

• Length: 183 bp

>T206711 NZ_CP102664:3192810-3193199 [Sphingobium sp. JS3065]
ATGCTCGACACCAATATCGTCTCCGATCTGCTGCGACATCCTGACGGCAGCGCGGCAAAGCGCATTGCCGAGGTCGGCCC
GGACGCGATTTGCGTGAGCATCATCACAGCCGCAGAGCTGCGATATGGGTGCGCCAGGAAAGGGTCTGCGAAACTCTTGG
CGCATGTCGAAGCGATATTGGAAAGTGTGCAGGTTCTGGCGCTCGATGTGCCTGCTGACGCGGAGTATGGCGGCATTCGC
GCCGAGCATGAGGCCGCGGGCAAGCCCATTGGTCCGAACGATCTGTTTATCGCAGCTCATGCCTACGCCGCAGGCGCAAT
CCTCGTGACTAACAACACGGGCGAGTTTTCCCGCATTCGCGGCCTGCAGGTTGAAAACTGGATCAGGTAG

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15543.66 Da
• Isoelectric Point: 4.6786

>AT206711 WP_186548485.1 NZ_CP077091:c3733598-3733173 [Pseudomonas hamedanensis]
MFEYALEVHEEPGSVWLTCAAIPEMHAVGDTLGEALDTAIDAIETAFSIYADDRRMIPTGHSGDQENDIVLRLPALTAAK
VALWNTLLESGLSKAELARRLGVQRPQVDRLVDFLHHSKIENVERALQQLGRRISLSVEAA

Nucleotide

• Length: 426 bp

>AT206711 NZ_CP102664:3192538-3192801 [Sphingobium sp. JS3065]
ATGCCGCATCCGCAGTCATATTCAGAGCCTCGTGAAGCCAAGCTCTTCCGTAACAACAAGAGCCAAGCCGTCCGCATTCC
CGCAGACTTCGAGATGCCGGGGGATCGGGTGAACATCTATCGTGATGGGAATCGGCTTATTATCGAGCCGGTGCGCCGCA
AGAACCTGCTTGAAGTGCTGGCCGGACTAGACCCGCTCGGGCCAGAGGATCAGTTTCCTGATGTGCACGAGACGCTTCTC
CCGGCCAAGGAAATCGACCTTTGA