Detailed information of TA system TA206703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2137231..2137847
• Replicon: chromosome
• Accession: NZ_CP077090
• Organism: Pseudomonas zeae strain OE 48.2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU754_RS09480
• Protein ID: WP_095050205.1
• Coordinates: 2137231..2137443 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HU754_RS09485
• Protein ID: WP_186625199.1
• Coordinates: 2137443..2137847 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU754_RS09455 (HU754_009455)	2132406..2134394	+	1989	WP_186625187.1	heme lyase CcmF/NrfE family subunit	-
HU754_RS09460 (HU754_009460)	2134391..2134927	+	537	WP_093439831.1	DsbE family thiol:disulfide interchange protein	-
HU754_RS09465 (HU754_009465)	2134924..2135394	+	471	WP_186625189.1	cytochrome c-type biogenesis protein CcmH	-
HU754_RS09470 (HU754_009470)	2135391..2136593	+	1203	WP_186625197.1	c-type cytochrome biogenesis protein CcmI	-
HU754_RS09475 (HU754_009475)	2136619..2137023	+	405	WP_016987493.1	hypothetical protein	-
HU754_RS09480 (HU754_009480)	2137231..2137443	+	213	WP_095050205.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU754_RS09485 (HU754_009485)	2137443..2137847	+	405	WP_186625199.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU754_RS09490 (HU754_009490)	2137917..2139104	-	1188	WP_186625201.1	MFS transporter	-
HU754_RS09495 (HU754_009495)	2139346..2139957	+	612	WP_186625203.1	DUF5666 domain-containing protein	-
HU754_RS09500 (HU754_009500)	2140197..2141195	-	999	WP_116256522.1	sulfate ABC transporter substrate-binding protein	-
HU754_RS09505 (HU754_009505)	2141300..2142124	-	825	WP_016987501.1	ion transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8044.22 Da
• Isoelectric Point: 10.3456

>T206703 WP_095050205.1 NZ_CP077090:2137231-2137443 [Pseudomonas zeae]
VQSRLLIKELEEAGWTLDRITGSHHIFRHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASFEGDP

Nucleotide

• Length: 213 bp

>T206703 NZ_CP102606:c939401-939015 [Thermus sp. PS18]
ATGGTCCTGGACACCTCAGCGGTCCTGGCGATCCTCCTTCGCGAGCCCGGTTACGAGACCTTGTTGCAGCGGATCGTCCG
CGGAGAGCCTCCAAAGATAGGGGCGCCTACCCTTGCGGAAGCTGGGATAGTGGTGGTAGCAAGGTTGGGGTTCAGCTATC
TCCATCTGCTTTACGAACTCCTGGAGGCGCTTGGAGCCGAGGTGATCCCCTTTACCGAGAAGCACGCTCGGGAAGCCATC
CGTGCCTATAAAGAGTTCGGCCGCGCCCAACACCCTGCGGGACTAAACTTCGGGGATTGCTTAAGCTATGCCACAGCCCG
TGTGGAGGGAATGCCTCTGCTCTATAAAGGCGACGACTTTGCCCAGACGGATTTAGGCCAAAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14757.65 Da
• Isoelectric Point: 4.2870

>AT206703 WP_186625199.1 NZ_CP077090:2137443-2137847 [Pseudomonas zeae]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYNAAVEVAHILLQEIAADGESIPMPTSASAHRSNPDFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Nucleotide

• Length: 405 bp

>AT206703 NZ_CP102606:c939662-939402 [Thermus sp. PS18]
ATGGCCTTCACCATACGCGATAAGGATGTGGAACGCCTGGTGGAGGAGGTGACCCGCCTCACCGGGGAGAGCAGGGCGGA
AGCGGTGCGGAAAGCCTTGGAGATGCGCCTTGCGGAGCTAAAACCCAGGCAAGGCCTTCAAAACCTTTTGCGCACCCTCG
AGGATAAAATCTGGTCCAAGATACCGCCGGAATACCTTGACAAGCCCCTTTCCCAAGAGGAAACGGAAAGGCTTCTGGGG
TATGGGCCCAAGGGGTTCTAG