Detailed information of TA system TA206700

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2072634..2073250
• Replicon: chromosome
• Accession: NZ_CP077089
• Organism: Pseudomonas tensinigenes strain ZA 5.3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU718_RS09160
• Protein ID: WP_186616616.1
• Coordinates: 2072634..2072846 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A7Z2KRV3
• Locus tag: HU718_RS09165
• Protein ID: WP_064390887.1
• Coordinates: 2072846..2073250 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU718_RS09135 (HU718_009135)	2067808..2069796	+	1989	WP_127926331.1	heme lyase CcmF/NrfE family subunit	-
HU718_RS09140 (HU718_009140)	2069793..2070329	+	537	WP_095119917.1	DsbE family thiol:disulfide interchange protein	-
HU718_RS09145 (HU718_009145)	2070326..2070796	+	471	WP_110720776.1	cytochrome c-type biogenesis protein CcmH	-
HU718_RS09150 (HU718_009150)	2070793..2071995	+	1203	WP_150729783.1	c-type cytochrome biogenesis protein CcmI	-
HU718_RS09155 (HU718_009155)	2072021..2072425	+	405	WP_095119920.1	hypothetical protein	-
HU718_RS09160 (HU718_009160)	2072634..2072846	+	213	WP_186616616.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU718_RS09165 (HU718_009165)	2072846..2073250	+	405	WP_064390887.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU718_RS09170 (HU718_009170)	2073320..2074507	-	1188	WP_186616617.1	MFS transporter	-
HU718_RS09175 (HU718_009175)	2074751..2075371	+	621	WP_150707789.1	DUF5666 domain-containing protein	-
HU718_RS09180 (HU718_009180)	2075612..2076610	-	999	WP_150707790.1	sulfate ABC transporter substrate-binding protein	-
HU718_RS09185 (HU718_009185)	2076715..2077539	-	825	WP_038363916.1	ion transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7988.20 Da
• Isoelectric Point: 10.2800

>T206700 WP_186616616.1 NZ_CP077089:2072634-2072846 [Pseudomonas tensinigenes]
VQSRLLIKELEEAGWTLDRVTGSHHIFKHRYNPYTIPVPHLKKDLPLGAVKSIRRRAGLYNPPASFEGDP

Nucleotide

• Length: 213 bp

>T206700 NZ_CP102604:c2574681-2574493 [Pantoea sp. SOD02]
ATGGATAGCAGATCATTAATGGCCGAGATTAAGGCCGATGGCTGGGAACTGATACGCGTGAACGGTAGCCACCACCATTT
TGTCCATCCGGTTAAAAAAGGGCTGGTGACGATACCGCATCCAAAAAAGGATTTGCCTGTCAAAACGGTGAAAAGTATCA
GGAAACAAGCCGGACTGACTGTCCATTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14789.75 Da
• Isoelectric Point: 4.3849

>AT206700 WP_064390887.1 NZ_CP077089:2072846-2073250 [Pseudomonas tensinigenes]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYKAAVEVAHIMLQEIAADGESIPMPTSASAHRSNPDFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Nucleotide

• Length: 405 bp

>AT206700 NZ_CP102604:c2574475-2574065 [Pantoea sp. SOD02]
ATGTTTTATCCCATCGCGATTGAGGCTGGCGACCAAAGCACGGCATTTGGCGTCACAGTGCCGGATTTGCCGGGCTGTTT
TTCTGCTGGAGATACGCTGGAAGCGGCGGTTAAGAATGCTAAAGAAGCGATTATCGGCCACCTGGAATTATTGGTCGAGT
TAGAGCAGGATATTCCGGCGGTTTCTGAACTGAAATCGCTGATGAAAGATCCGCAATATGCAGGTTATGTTTGGGTTCTC
ATCGATGTGGATGTCACTCGCATCCTGGGTGGATCGGAGAAAATCAACGTAACCTTGCCAAAATTGCTGATTGATCGCAT
CGACCGCTGCGTAGCAACGCATCCCGAATTCAAAACCCGTTCAGGCTTCCTGGCGCAGGTGGCGCTAGAGCGGATTGCAA
AAACCAGCTAG

Structures

Antitoxin

• AlphaFold DB: A0A7Z2KRV3