Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1765262..1765885 Replicon chromosome
Accession NZ_CP077089
Organism Pseudomonas tensinigenes strain ZA 5.3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HU718_RS07820 Protein ID WP_186612660.1
Coordinates 1765706..1765885 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HU718_RS07815 Protein ID WP_102900240.1
Coordinates 1765262..1765669 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU718_RS07785 (HU718_007785) 1760269..1760679 - 411 WP_007911483.1 low affinity iron permease family protein -
HU718_RS07790 (HU718_007790) 1760844..1761614 + 771 WP_186612652.1 trans-aconitate 2-methyltransferase -
HU718_RS07795 (HU718_007795) 1761817..1762545 - 729 WP_186612654.1 class I SAM-dependent methyltransferase -
HU718_RS07800 (HU718_007800) 1763110..1763472 + 363 WP_186612656.1 DUF6124 family protein -
HU718_RS07805 (HU718_007805) 1763549..1764808 - 1260 WP_186612658.1 type II toxin-antitoxin system HipA family toxin -
HU718_RS07810 (HU718_007810) 1764801..1765118 - 318 WP_102900239.1 helix-turn-helix transcriptional regulator -
HU718_RS07815 (HU718_007815) 1765262..1765669 - 408 WP_102900240.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HU718_RS07820 (HU718_007820) 1765706..1765885 - 180 WP_186612660.1 type II toxin-antitoxin system HicA family toxin Toxin
HU718_RS07825 (HU718_007825) 1766249..1766767 + 519 WP_110720088.1 hypothetical protein -
HU718_RS07835 (HU718_007835) 1767286..1768170 - 885 WP_007911470.1 alpha/beta hydrolase -
HU718_RS07840 (HU718_007840) 1768487..1769179 - 693 WP_038358303.1 pseudouridine synthase -
HU718_RS07845 (HU718_007845) 1769214..1769444 - 231 WP_064119704.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6662.97 Da        Isoelectric Point: 11.1923

>T206699 WP_186612660.1 NZ_CP077089:c1765885-1765706 [Pseudomonas tensinigenes]
VNSRFLIGQLVADGWYLVRIKGSHHHFKHPTKLGLVTVPHPKKDLLKKTAISILQQALL

Download         Length: 180 bp

>T206699 NZ_CP102604:c1699096-1698914 [Pantoea sp. SOD02]
ATGAAAAGCTCTGAGCTAATTAAAATGCTGGTGAACACCGGATGGAGTCTTGAAAGAATCAAAGGCAGTCATCATCAGTT
CTCCCATCCTGATTTCAGTTATCTCATCACCGTTCCGCACCCGCGAAAGGACCTAAAAACAGGAACGCTGATGCAGATTT
TGAAGGACGCCAAACTTAAATAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14540.57 Da        Isoelectric Point: 4.5911

>AT206699 WP_102900240.1 NZ_CP077089:c1765669-1765262 [Pseudomonas tensinigenes]
MLYPIAISIGDDQHAWGVEVPDIPGCFSAGEDLDDAVAMAREAIEGHFEILADDDAPIPAASKLSLHVANPKYAGCAWAV
VDIDVLKYLGKAQKLNITLPGHLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT206699 NZ_CP102604:c1698873-1698478 [Pantoea sp. SOD02]
ATGTTGTATCCCGCCTTTGTTGAAATTGATGTTGATGGCTCTGCCAGCGGTTTCTTCCCTGACGTAACCGGCTGCTACTT
TGCTGGAGATACGCCAGAGCACACCCTTTACGATGCCCAGTCTGCGCTGAGTGCGCATTTTGAATTAATGGCAGAGAAAA
GCATGCTCATTCCCGAACCTTCGCAGAATTGGATCACCGATTTTAGCCAGACAGGAATTTGGATTTATGTTGAGATCGAT
ATTACGCGCTATCTAGGTAAATCTGAGCGCATCAACATCACTATGCCGAACTTGTTGATTGAGAAGATAGATCAGGCCGT
GGGGAATGATGCGCGCTATAACAGCCGCAGCCACTTTCTCGCTGAAGCCGCGCGTAAAGCGTTATCACACTCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References