Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 710680..711269 Replicon chromosome
Accession NZ_CP077089
Organism Pseudomonas tensinigenes strain ZA 5.3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HU718_RS03120 Protein ID WP_102899512.1
Coordinates 710680..710985 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HU718_RS03125 Protein ID WP_038360089.1
Coordinates 710982..711269 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU718_RS03100 (HU718_003100) 706466..707533 + 1068 WP_016983859.1 uroporphyrinogen decarboxylase -
HU718_RS03105 (HU718_003105) 707726..709000 - 1275 WP_186612988.1 MFS transporter -
HU718_RS03110 (HU718_003110) 709119..710021 + 903 WP_016983863.1 LysR family transcriptional regulator -
HU718_RS03115 (HU718_003115) 710126..710563 - 438 WP_186612986.1 excinuclease -
HU718_RS03120 (HU718_003120) 710680..710985 + 306 WP_102899512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU718_RS03125 (HU718_003125) 710982..711269 + 288 WP_038360089.1 putative addiction module antidote protein Antitoxin
HU718_RS03130 (HU718_003130) 711327..712130 - 804 WP_150708724.1 hypothetical protein -
HU718_RS03135 (HU718_003135) 712156..713382 - 1227 WP_016983866.1 beta-ketoacyl-ACP synthase -
HU718_RS03140 (HU718_003140) 713382..714110 - 729 WP_150708723.1 3-ketoacyl-ACP reductase FabG2 -
HU718_RS03145 (HU718_003145) 714103..714567 - 465 WP_186612983.1 hotdog family protein -
HU718_RS03150 (HU718_003150) 714564..715760 - 1197 WP_186612982.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-82)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11534.19 Da        Isoelectric Point: 9.6535

>T206698 WP_102899512.1 NZ_CP077089:710680-710985 [Pseudomonas tensinigenes]
MTEILRSSTFSNWLLKLADSRARMRIQVRIDRMADGNFGDVKAIGEGLSEVRIDYGPGYRVYFMQQGRQVVILLCGGDKS
SQPRDIKQARLIAESWQEQNP

Download         Length: 306 bp

>T206698 NZ_CP102604:c1131020-1130802 [Pantoea sp. SOD02]
ATGAGCAACCAAGCCTTAACCAAAACAGATTATTTGATGCGACTGCGCCGCTGTCGCTCAATCGATACCCTTGAACGGGT
TATCGAAAAAAACAAGTATGAATTACCTGATAATGAACTCGCGGTATTCTATTCGGCAGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTTTACGATAAAGTACCGGTTTCTGTCTGGAAGTTCGTCCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10372.76 Da        Isoelectric Point: 4.8483

>AT206698 WP_038360089.1 NZ_CP077089:710982-711269 [Pseudomonas tensinigenes]
MTEKFTRWDSAEYLKTEEDMANYLDACMEEAGDDPAFIAKALGTIARARGMTQVARDAGLSRESLYRALSGEGNPEFGTI
LKVVKALGLKLHAST

Download         Length: 288 bp

>AT206698 NZ_CP102604:c1131422-1131045 [Pantoea sp. SOD02]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTGTGTGAGAACTTGTTCGACGAAAGTATGGC
GACATTGACTGATAGCCATCATGGTTGGGTTAATGATCCTACTTCGGAAAGCAATTTACAGCTCAACGATTTGATTGAGC
ATATCGCTTCTTTCACGATGAATTACAAAATTAAGCACGTTGAAGATGAAGCCCTGATTACGCAAATCGATGAATATCTT
GACGATACCTTTATGCTGTTCAGCAGCTATGGAATCAATACTCAGGATCTTCAACGGTGGCAGCGTTCAGCAAAACGTTT
ATTTAATCTGTTTGCCGAAGAGTGTGCTTATCTCCAACAACCTAGCCATTCCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References