Detailed information of TA system TA206695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2571729..2572209
• Replicon: chromosome
• Accession: NZ_CP077087
• Organism: Pseudomonas monsensis strain PGSB 8459

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV782_RS11295
• Protein ID: WP_186747848.1
• Coordinates: 2571729..2572013 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4V6Q6W5
• Locus tag: HV782_RS11300
• Protein ID: WP_034152589.1
• Coordinates: 2572003..2572209 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV782_RS11260 (HV782_011265)	2567123..2567596	+	474	WP_123463232.1	type II secretion system protein	-
HV782_RS11265 (HV782_011270)	2567602..2567976	+	375	WP_064588154.1	type II secretion system protein	-
HV782_RS11270 (HV782_011275)	2567951..2568490	+	540	WP_186747841.1	type II secretion system protein	-
HV782_RS11275 (HV782_011280)	2568487..2568879	+	393	WP_093439237.1	curli production assembly/transport protein CsgE	-
HV782_RS11280 (HV782_011285)	2568876..2569307	+	432	WP_128615748.1	curli assembly protein CsgF	-
HV782_RS11285 (HV782_011290)	2569337..2570197	+	861	WP_186747843.1	CsgG/HfaB family protein	-
HV782_RS11290 (HV782_011295)	2571177..2571548	+	372	WP_186747846.1	DUF6124 family protein	-
HV782_RS11295 (HV782_011300)	2571729..2572013	-	285	WP_186747848.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV782_RS11300 (HV782_011305)	2572003..2572209	-	207	WP_034152589.1	hypothetical protein	Antitoxin
HV782_RS11305 (HV782_011310)	2572486..2573937	-	1452	WP_186747850.1	curlin	-
HV782_RS11310 (HV782_011315)	2573966..2574430	-	465	WP_128616044.1	curlin	-
HV782_RS11315 (HV782_011320)	2574503..2576737	-	2235	WP_186747853.1	Ig-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10910.75 Da
• Isoelectric Point: 10.6629

>T206695 WP_186747848.1 NZ_CP077087:c2572013-2571729 [Pseudomonas monsensis]
MQIKWRPKARVELSKILKYIGERNFLAATALHKSVVKTTSALCWHPHLYRKGRSPGTREIVVSPNYLVVYQVADQIEIVS
ILHTRQEYPRRDPG

Nucleotide

• Length: 285 bp

>T206695 NZ_CP102603:c1947460-1947110 [Bacillus amyloliquefaciens]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAGAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7672.54 Da
• Isoelectric Point: 3.8068

>AT206695 WP_034152589.1 NZ_CP077087:c2572209-2572003 [Pseudomonas monsensis]
MIDPSLIDPLCPVVSDLDPEEQAASYDRWFRAEVQASLDDPRPSIPHEQVMEEINALMESMRKSADAD

Nucleotide

• Length: 207 bp

>AT206695 NZ_CP102603:c1947747-1947466 [Bacillus amyloliquefaciens]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A4V6Q6W5