Detailed information of TA system TA206694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 942020..942616
• Replicon: chromosome
• Accession: NZ_CP077087
• Organism: Pseudomonas monsensis strain PGSB 8459

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV782_RS04000
• Protein ID: WP_186747487.1
• Coordinates: 942314..942616 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W6VRS3
• Locus tag: HV782_RS03995
• Protein ID: WP_003221244.1
• Coordinates: 942020..942310 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV782_RS03975 (HV782_003975)	938319..940439	-	2121	WP_186747491.1	TonB-dependent copper receptor	-
HV782_RS03980 (HV782_003980)	940525..940977	-	453	WP_186747489.1	DUF2946 domain-containing protein	-
HV782_RS03985 (HV782_003985)	940999..941475	-	477	WP_123471016.1	copper chaperone PCu(A)C	-
HV782_RS03990 (HV782_003990)	941524..941922	-	399	WP_123471018.1	DUF2946 domain-containing protein	-
HV782_RS03995 (HV782_003995)	942020..942310	-	291	WP_003221244.1	putative addiction module antidote protein	Antitoxin
HV782_RS04000 (HV782_004000)	942314..942616	-	303	WP_186747487.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV782_RS04005 (HV782_004005)	942776..943504	-	729	WP_186747484.1	cobalt-precorrin-6A reductase	-
HV782_RS04010 (HV782_004010)	943501..944598	-	1098	WP_186747482.1	cobalt-precorrin-5B (C(1))-methyltransferase	-
HV782_RS04015 (HV782_004015)	944591..945802	-	1212	WP_186747480.1	precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE	-
HV782_RS04020 (HV782_004020)	945935..947233	+	1299	WP_275970831.1	precorrin-3B synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (4-93)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11658.28 Da
• Isoelectric Point: 8.4251

>T206694 WP_186747487.1 NZ_CP077087:c942616-942314 [Pseudomonas monsensis]
MIELERSRVFSEWLDSLKDIIGKGRIISRLRAAEHGNFGDYGFVGDTVYEMRVHYGPGYRMYFTRRDEVIYLLLIGGDKS
TQRRDIKRAVQMAHSIGNEE

Nucleotide

• Length: 303 bp

>T206694 NZ_CP102603:1205694-1206440 [Bacillus amyloliquefaciens]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
AGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGAGTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGGACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10430.91 Da
• Isoelectric Point: 4.6027

>AT206694 WP_003221244.1 NZ_CP077087:c942310-942020 [Pseudomonas monsensis]
MTEKFTRFDAAEYLKTPEDMAAYLDACFDDDEGDGVLIRAALNDIARAQGMTQVARDAGLGRESLYKALSSTGNPEFATI
MKVMKALGLRLHAVAV

Nucleotide

• Length: 291 bp

>AT206694 NZ_CP102603:1206441-1206611 [Bacillus amyloliquefaciens]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Antitoxin

• AlphaFold DB: W6VRS3