Detailed information of TA system TA206692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4383322..4383869
• Replicon: chromosome
• Accession: NZ_CP077086
• Organism: Pseudomonas zarinae strain SWRI108

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G8Q8L6
• Locus tag: HU749_RS19095
• Protein ID: WP_014337667.1
• Coordinates: 4383594..4383869 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G8Q8L7
• Locus tag: HU749_RS19090
• Protein ID: WP_014337668.1
• Coordinates: 4383322..4383594 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU749_RS19075 (HU749_019075)	4379668..4381200	+	1533	WP_014337671.1	NADH-quinone oxidoreductase subunit M	-
HU749_RS19080 (HU749_019080)	4381208..4382671	+	1464	WP_003203388.1	NADH-quinone oxidoreductase subunit NuoN	-
HU749_RS19085 (HU749_019085)	4382808..4383140	-	333	Protein_3805	GNAT family N-acetyltransferase	-
HU749_RS19090 (HU749_019090)	4383322..4383594	+	273	WP_014337668.1	ribbon-helix-helix domain-containing protein	Antitoxin
HU749_RS19095 (HU749_019095)	4383594..4383869	+	276	WP_014337667.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU749_RS19100 (HU749_019100)	4383933..4385042	+	1110	WP_186649780.1	NAD(P)/FAD-dependent oxidoreductase	-
HU749_RS19105 (HU749_019105)	4385241..4385717	+	477	WP_003203396.1	hemerythrin domain-containing protein	-
HU749_RS19110 (HU749_019110)	4385773..4386651	-	879	WP_079302265.1	LysR family transcriptional regulator	-
HU749_RS19115 (HU749_019115)	4386893..4387522	-	630	WP_014337664.1	isochorismate family cysteine hydrolase YcaC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10619.17 Da
• Isoelectric Point: 9.5555

>T206692 WP_014337667.1 NZ_CP077086:4383594-4383869 [Pseudomonas zarinae]
MELKWTSKALSDIARLYEFLAAVNQPAAARTVQQLTAAPTSLLANPRIGERLEEFEPRDVRRIQVGRYEMRYEIAGSTLY
LLRLWHTREDR

Nucleotide

• Length: 276 bp

>T206692 NZ_CP102602:682508-682909 [Thermococcus sp. 813A4]
ATGCGCGGAGTGATAGACACGAACGTTCTGATATACGACACCTTCGAGGACTCCGAGTTTCACGGCGAGGCTGAGAGGAT
TCTCGAATCGCTGGACGCGTGGTACGTGCCGACGATAGTCCTCCAAGAGTTTGCTTGGTTCTTCAGGAATGAGGGGTTTT
CCGCCGATGAGACGTGGGAAGTTCTGAGGGGATACCTCGATGACCCAAGGTTCAGGGGGCTCAACGATGATTCACAAATC
GTGAAAAAGGCTTTTGAGATACTAAAGGTTGAGAAACTTTCCCTCTCCCGCTTCAACGACGCGATGATTTTAGTCCATGC
CGTTGAGAAGGGTGTTTTGGTGACGTTCGATTCAAAGTTCAGGAAATTAGCCGAGAGAAGGGGCGTTAAAGTCCTCCCGT
AG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10108.40 Da
• Isoelectric Point: 6.0741

>AT206692 WP_014337668.1 NZ_CP077086:4383322-4383594 [Pseudomonas zarinae]
MTTTAKTRSVTAHVPVHLAEKVDLMAERLERSRNWIVKQALSAWIEQEEERSRLTHEALADVDAGRVIDHQAVQAWADSL
STDAPLPVPR

Nucleotide

• Length: 273 bp

>AT206692 NZ_CP102602:682293-682520 [Thermococcus sp. 813A4]
ATGGGCGTTACCAAAGTAACCCGAAACTACCAGATAACAATTCCAGCAGAGATAAGGAAGGCGCTCGGCATAAAGGAGGG
GGAGCTCCTCGAAGTTCACCTTGAAGGCGACAGGATAGTCCTGAAAAGGCTGGAGAGGAAGAGAAAAAGGCTCAGACTAA
GAAGGAAGCTCACTCCCAAGGACATCGAGAAGGCCATCGAGGAGGGCATGAAGGAATGCGCGGAGTGA

Structures

Toxin

• AlphaFold DB: G8Q8L6

Antitoxin

• AlphaFold DB: G8Q8L7