Detailed information of TA system TA206691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2603410..2603929
• Replicon: chromosome
• Accession: NZ_CP077086
• Organism: Pseudomonas zarinae strain SWRI108

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HU749_RS11590
• Protein ID: WP_186650661.1
• Coordinates: 2603648..2603929 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A176NDU7
• Locus tag: HU749_RS11585
• Protein ID: WP_024616638.1
• Coordinates: 2603410..2603658 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU749_RS11570 (HU749_011570)	2599839..2600837	+	999	WP_079302487.1	AAA family ATPase	-
HU749_RS11575 (HU749_011575)	2600939..2601496	+	558	WP_186650659.1	VWA domain-containing protein	-
HU749_RS11580 (HU749_011580)	2601697..2603343	+	1647	WP_095963081.1	phospholipase D-like domain-containing protein	-
HU749_RS11585 (HU749_011585)	2603410..2603658	+	249	WP_024616638.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HU749_RS11590 (HU749_011590)	2603648..2603929	+	282	WP_186650661.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU749_RS11595 (HU749_011595)	2604038..2604379	+	342	WP_079302489.1	hypothetical protein	-
HU749_RS11600 (HU749_011600)	2604718..2605566	+	849	WP_003200222.1	transporter substrate-binding domain-containing protein	-
HU749_RS11605 (HU749_011605)	2605621..2606283	+	663	WP_186650663.1	amino acid ABC transporter permease	-
HU749_RS11610 (HU749_011610)	2606293..2606955	+	663	WP_186650665.1	amino acid ABC transporter permease	-
HU749_RS11615 (HU749_011615)	2606952..2607758	+	807	WP_046062045.1	amino acid ABC transporter ATP-binding protein	-
HU749_RS11620 (HU749_011620)	2607798..2608184	+	387	WP_134923748.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10889.62 Da
• Isoelectric Point: 10.1953

>T206691 WP_186650661.1 NZ_CP077086:2603648-2603929 [Pseudomonas zarinae]
MTYELEFSDKAWKEWQKLGATLKEQFKKKLEERLVNPHVQADRLHGLGNAYKIKLRNAGYRLVYRVVDDLLVVTVIAVGK
RERGQVYDEAAKR

Nucleotide

• Length: 282 bp

>T206691 NZ_CP102602:c574537-574139 [Thermococcus sp. 813A4]
GTGATAGCAATTGACGCCTCCGTCCTTGCGAAGTACATCCTCCTCGAACCCGGCTGGGAACAGGTGGAGGAACTGCTCCT
AAAAGACGTTATCTCGCTTGACTACGCCTTGGTAGAGGTCTCAAACGCCCTCTGGAAGCATCACGTCCTCTACGGAAGAA
TCTCACGGGAGGAGTTTGAGAGAAGGTCCCGCGTGATTGACGCGATCCCCAATGTGGTTGTTCTGGAAAACGGAGTTGAG
TATCTTCCACCTGCGAGGGGTATAGCTCTGGAGCACAAAATCACGGTTTATGACGCCCTCTACATCGCCCAGGCACTCAA
ATACGGAAAGCTCGCCACGAGCGATGAAAAGCAGGGAGAAATAGCAAAAAAACTCGGCATCGAGGTGTTCTACCTCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9037.44 Da
• Isoelectric Point: 4.4000

>AT206691 WP_024616638.1 NZ_CP077086:2603410-2603658 [Pseudomonas zarinae]
MTHIVLSQVVASISELKKNPMGTVAAGGGLSVAILNRNEPAFYCVPAREYEAMMDRLEDMELVALCRERENDPTIKVSLD
DL

Nucleotide

• Length: 249 bp

>AT206691 NZ_CP102602:c574745-574524 [Thermococcus sp. 813A4]
ATGGCCGTCATAAGCGTCCGCGTTCCGGACGAGCTAAAGGAGAAGATGAAGAAGTACGACATTAACTGGAGCGAGGAGAT
AAGGAGGTTCATAGCTTTGAGGATAAGCAAAGAGGAAAAGAAAAGAACCCTTGAGAGGATGCACGAATTGCTTGCCGGAG
GAACCCCCACCAGGGAAGGGACCGCAAAAAGATATGTGAGGGAGGATCGTGATAGCAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A176NDU7