Detailed information of TA system TA206689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2391623..2392236
• Replicon: chromosome
• Accession: NZ_CP077085
• Organism: Pseudomonas shahriarae strain SWRI52

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU773_RS10880
• Protein ID: WP_057439099.1
• Coordinates: 2391985..2392236 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HU773_RS10875
• Protein ID: WP_186626264.1
• Coordinates: 2391623..2391988 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU773_RS10855 (HU773_010855)	2387027..2388178	+	1152	WP_057439103.1	HlyD family secretion protein	-
HU773_RS10860 (HU773_010860)	2388168..2389688	+	1521	WP_057959158.1	MDR family MFS transporter	-
HU773_RS10865 (HU773_010865)	2389722..2390306	-	585	WP_186626263.1	TetR/AcrR family transcriptional regulator	-
HU773_RS10870 (HU773_010870)	2390449..2391621	+	1173	WP_120732481.1	MFS transporter	-
HU773_RS10875 (HU773_010875)	2391623..2391988	-	366	WP_186626264.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU773_RS10880 (HU773_010880)	2391985..2392236	-	252	WP_057439099.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9434.03 Da
• Isoelectric Point: 9.5640

>T206689 WP_057439099.1 NZ_CP077085:c2392236-2391985 [Pseudomonas shahriarae]
VSKNEKLLAKLLNLQMAFTWPELVTLLGWLGYRQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKYYIRRQIIEQLESGG
LIQ

Nucleotide

• Length: 252 bp

>T206689 NZ_CP102594:c4574860-4574726 [Xanthomonas sp. CFBP 8445]
ATGAAGCGTACATTTGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCCGGCTGCAACACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCGGGCGAGAAGGTCGAAGACGCTGCCAAGAACTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13327.17 Da
• Isoelectric Point: 7.4017

>AT206689 WP_186626264.1 NZ_CP077085:c2391988-2391623 [Pseudomonas shahriarae]
VSNQLKHKGYIGSIEASVEDNCLFGKLLFIRPLVSYEGQTVAQLEAAFREAVEDYLVTCQTLGQAPEKPCKGSFNVRVGH
DLHLAAALAATQKKVTLNDLTRQALNEFLRHHRTDSHPALG

Nucleotide

• Length: 366 bp

>AT206689 NZ_CP102594:c4575066-4574914 [Xanthomonas sp. CFBP 8445]
ATGAAGCGACTGACCACCCTGTTGATGCTGACCCTGTTCTGCGCTGGCGTGCTGACCGGCTGCAACACCGTTGCCGGCGC
CGGCAAGGACATGCAGAAGGCGGGCGAGAAGGTGGAAGACAAGGCGCAGGATTGCAGCGCTGGCAAGTGCTGA