Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1921833..1922450 Replicon chromosome
Accession NZ_CP077085
Organism Pseudomonas shahriarae strain SWRI52

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HU773_RS08675 Protein ID WP_057438840.1
Coordinates 1921833..1922021 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HU773_RS08680 Protein ID WP_057438841.1
Coordinates 1922046..1922450 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU773_RS08645 (HU773_008645) 1916939..1917781 + 843 WP_057438836.1 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ -
HU773_RS08650 (HU773_008650) 1917742..1918551 + 810 WP_120734408.1 phosphonate C-P lyase system protein PhnK -
HU773_RS08655 (HU773_008655) 1918548..1919270 + 723 WP_120732262.1 phosphonate C-P lyase system protein PhnL -
HU773_RS08660 (HU773_008660) 1919260..1920405 + 1146 WP_057438838.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
HU773_RS08665 (HU773_008665) 1920405..1920971 + 567 WP_186625969.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
HU773_RS08670 (HU773_008670) 1920962..1921711 + 750 WP_057958969.1 phosphonate metabolism protein PhnP -
HU773_RS08675 (HU773_008675) 1921833..1922021 + 189 WP_057438840.1 type II toxin-antitoxin system HicA family toxin Toxin
HU773_RS08680 (HU773_008680) 1922046..1922450 + 405 WP_057438841.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HU773_RS08685 (HU773_008685) 1922809..1924323 + 1515 WP_178118158.1 M10 family metallopeptidase C-terminal domain-containing protein -
HU773_RS08690 (HU773_008690) 1924347..1925543 - 1197 WP_057438842.1 MFS transporter -
HU773_RS08695 (HU773_008695) 1925774..1926778 - 1005 WP_169990453.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7132.31 Da        Isoelectric Point: 11.4962

>T206687 WP_057438840.1 NZ_CP077085:1921833-1922021 [Pseudomonas shahriarae]
VQSRLLIKELQEAGWVLDRVMGSHHIFTHRYNPSTIPVPHPKKDLPLGTVRSIRQRAGLFSF

Download         Length: 189 bp

>T206687 NZ_CP102594:3619902-3620153 [Xanthomonas sp. CFBP 8445]
ATGGACACCATCACCTACAGCGCCGCACGTGCCGCTCTTGCGGACACCATGGACCGCGTGGTCAACAACCACGAGCCGGT
GATCATCACGCGCAGCCGCGAGCAAGCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTATC
TGCTGCGCAGTCCGAAGAACGCGCAGCGCCTGCTGGAATCCATCGCCCAACTCGAATCCGGTCGCGGCAAGGCACGGGAA
CTGAGCGAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14706.68 Da        Isoelectric Point: 4.6115

>AT206687 WP_057438841.1 NZ_CP077085:1922046-1922450 [Pseudomonas shahriarae]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHILLQELAGEGRAIPMPTSVATHHGNEEYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT206687 NZ_CP102594:3620150-3620407 [Xanthomonas sp. CFBP 8445]
GTGACGCTGCAGTTCTCGGACAACGCCTGGGAGGATTATCTCTACTGGCAACAGGCCGACAAAAAGATGCTCAAGCGCAT
CAACGACCTGATCAAGGCCATTCAACGCGATCCCTTCCAGGGCATCGGCAAACCCGAACCGCTACGCCATGCACTTGCAG
GCTACTGGTCGCGACGCATCAACGACGAACACCGGATCATCTATAAGGTCGAGCATGGCGTCCTGCTGATTGCACAGGTC
CGATATCACTACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References