Detailed information of TA system TA206686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1660284..1660899
• Replicon: chromosome
• Accession: NZ_CP077085
• Organism: Pseudomonas shahriarae strain SWRI52

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU773_RS07405
• Protein ID: WP_115127579.1
• Coordinates: 1660717..1660899 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HU773_RS07400
• Protein ID: WP_057439755.1
• Coordinates: 1660284..1660694 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU773_RS07365 (HU773_007365)	1655827..1656302	+	476	Protein_1452	hypothetical protein	-
HU773_RS07370 (HU773_007370)	1656307..1656795	-	489	WP_186625230.1	DMT family transporter	-
HU773_RS07375 (HU773_007375)	1656864..1657790	+	927	WP_186625232.1	LysR family transcriptional regulator	-
HU773_RS07380 (HU773_007380)	1657854..1658495	+	642	WP_128593594.1	LysE family translocator	-
HU773_RS07385 (HU773_007385)	1658614..1659141	+	528	WP_057439756.1	DUF4142 domain-containing protein	-
HU773_RS07390 (HU773_007390)	1659527..1659673	+	147	WP_164844853.1	hypothetical protein	-
HU773_RS07395 (HU773_007395)	1659687..1660187	-	501	WP_057958770.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
HU773_RS07400 (HU773_007400)	1660284..1660694	-	411	WP_057439755.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU773_RS07405 (HU773_007405)	1660717..1660899	-	183	WP_115127579.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU773_RS07415 (HU773_007415)	1661355..1662239	-	885	WP_120732097.1	alpha/beta hydrolase	-
HU773_RS07420 (HU773_007420)	1662535..1663227	-	693	WP_057439752.1	pseudouridine synthase	-
HU773_RS07425 (HU773_007425)	1663227..1663439	-	213	WP_057439751.1	cysteine-rich CWC family protein	-
HU773_RS27360	1663657..1664016	+	360	WP_081044197.1	hypothetical protein	-
HU773_RS07430 (HU773_007430)	1664162..1664590	+	429	WP_057958775.1	DUF3757 domain-containing protein	-
HU773_RS07435 (HU773_007435)	1664613..1665725	-	1113	WP_057439749.1	enoyl-CoA hydratase/isomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6766.01 Da
• Isoelectric Point: 10.9646

>T206686 WP_115127579.1 NZ_CP077085:c1660899-1660717 [Pseudomonas shahriarae]
VDSRYLIGHIVADGWYLVRVRGSHHHFKHPAKPGLVTIPHPKKHLLDKTAKSILKQALLA

Nucleotide

• Length: 183 bp

>T206686 NZ_CP102593:c5210987-5210706 [Xanthomonas campestris pv. phormiicola]
GTGATCCGGAACTTCGTCGACAAGGAAGCCGAAAAGATCTGGCAGGGCACGCCTTCACGGCGATTGCCGGCCGATATCCA
GGCTGTGGCTCGGCGCAAGCTACGCATGCTCAACAGCGCGGCCATACTGGACGACTTGCGTGTTCCACCGGCCGACCATC
TGGAAGCGTTGAAGGGCAATCGCAAGGGCCAATACAGCATCCGGATCAACGATCAATCGCGTGTGTGCTTCCAATGGAAG
GACGGCGATGCGCTGGACGTGGAAATCGTCGACTACCACTGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14789.76 Da
• Isoelectric Point: 4.4077

>AT206686 WP_057439755.1 NZ_CP077085:c1660694-1660284 [Pseudomonas shahriarae]
MLYPIAISTGDDDHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFELLAEEGAPIPSAQKVTLHAANPLYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQER

Nucleotide

• Length: 411 bp

>AT206686 NZ_CP102593:c5210691-5210401 [Xanthomonas campestris pv. phormiicola]
ATGAAGACCCTGCCCAACATCCACCCCGGCGAAGTCCTGCTGGAGGAATTCCTGACCCCGCTGGGCATCAGCCAGAACGC
ACTGGCGCGCGCCGCCGGCGTGCCGCCGCGCCGCATCAACGAAATCGTGCTCGGCAAGCGCAGCGTGAGCGCCGACAGCG
CGATCCGGCTGGCCGCCGCGCTCGGCACCAGCGAGCGCTTCTGGCTCGGCCTGCAGGCCGACTACGACCTGGAACAGGCG
CGGCGCGCGCTGGGCGCGCAGGCGCGCAAGATCGAGCGCATCGCGGCGTAG