206679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1833552..1834167 Replicon chromosome
Accession NZ_CP077084
Organism Pseudomonas tritici strain SWRI145

Toxin (Protein)


Gene name hicA Uniprot ID A0A8H9YY47
Locus tag HU722_RS08145 Protein ID WP_065874722.1
Coordinates 1833985..1834167 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8H9YZ86
Locus tag HU722_RS08140 Protein ID WP_065874721.1
Coordinates 1833552..1833962 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU722_RS08110 (HU722_0008110) 1829343..1829831 - 489 WP_065874714.1 DMT family transporter -
HU722_RS08115 (HU722_0008115) 1829900..1830826 + 927 WP_186754363.1 LysR substrate-binding domain-containing protein -
HU722_RS08120 (HU722_0008120) 1830840..1831250 + 411 WP_065874716.1 fosfomycin resistance glutathione transferase -
HU722_RS08125 (HU722_0008125) 1831437..1831964 + 528 WP_065874717.1 DUF4142 domain-containing protein -
HU722_RS08130 (HU722_0008130) 1832018..1832443 - 426 WP_065874718.1 low affinity iron permease family protein -
HU722_RS08135 (HU722_0008135) 1832559..1833059 - 501 WP_065874719.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
HU722_RS08140 (HU722_0008140) 1833552..1833962 - 411 WP_065874721.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HU722_RS08145 (HU722_0008145) 1833985..1834167 - 183 WP_065874722.1 type II toxin-antitoxin system HicA family toxin Toxin
HU722_RS08150 (HU722_0008150) 1834336..1835229 - 894 WP_065874723.1 LysR family transcriptional regulator -
HU722_RS08155 (HU722_0008155) 1835325..1836488 + 1164 WP_065882075.1 MFS transporter -
HU722_RS08160 (HU722_0008160) 1836485..1837675 + 1191 WP_065946172.1 MFS transporter -
HU722_RS08165 (HU722_0008165) 1837999..1838238 + 240 WP_065882079.1 DUF6124 family protein -
HU722_RS08170 (HU722_0008170) 1838319..1838624 - 306 WP_065874727.1 DUF6482 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6776.00 Da        Isoelectric Point: 10.6682

>T206679 WP_065874722.1 NZ_CP077084:c1834167-1833985 [Pseudomonas tritici]
VDSRYLIGHIVADGWYLVRIKGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS

Download         Length: 183 bp

>T206679 NZ_CP102592:445785-445919 [Xanthomonas sp. CFBP 8443]
ATGAAGCGTACTTTTGCGTGGATGCTGCTGGCGATGTTCTCGGTCGGCCTGCTGTCTGGCTGCAACACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14689.56 Da        Isoelectric Point: 4.4699

>AT206679 WP_065874721.1 NZ_CP077084:c1833962-1833552 [Pseudomonas tritici]
MLYPIAISTGDDDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPSAQKVTLHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQGH

Download         Length: 411 bp

>AT206679 NZ_CP102592:445537-445689 [Xanthomonas sp. CFBP 8443]
ATGAAGCGACTGCTCACCTTGATGATGCTGACCCTGTTCTGTGCGGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
CGGCAAAGACATGCAGAAGGCGGGCGAGAAGGTGGAAGACAAGGCGGGCGATTGCAGCGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References