Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 5141471..5142085 | Replicon | chromosome |
| Accession | NZ_CP077083 | ||
| Organism | Pseudomonas salmasensis strain SWRI126 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | I4KFU3 |
| Locus tag | HU731_RS23060 | Protein ID | WP_003189411.1 |
| Coordinates | 5141903..5142085 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A9E6ND06 |
| Locus tag | HU731_RS23055 | Protein ID | WP_032893068.1 |
| Coordinates | 5141471..5141881 (-) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HU731_RS23015 (HU731_023015) | 5136539..5137015 | - | 477 | WP_186605720.1 | DMT family transporter | - |
| HU731_RS23020 (HU731_023020) | 5137084..5137998 | + | 915 | WP_186605722.1 | LysR family transcriptional regulator | - |
| HU731_RS23025 (HU731_023025) | 5138006..5138290 | - | 285 | WP_186605724.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HU731_RS23030 (HU731_023030) | 5138280..5138519 | - | 240 | WP_186605726.1 | ribbon-helix-helix protein, CopG family | - |
| HU731_RS23035 (HU731_023035) | 5138621..5139037 | + | 417 | WP_186605728.1 | fosfomycin resistance glutathione transferase | - |
| HU731_RS23040 (HU731_023040) | 5139085..5139726 | + | 642 | WP_186605731.1 | LysE family translocator | - |
| HU731_RS23045 (HU731_023045) | 5139846..5140373 | + | 528 | WP_003189402.1 | DUF4142 domain-containing protein | - |
| HU731_RS23050 (HU731_023050) | 5140460..5140960 | - | 501 | WP_186605733.1 | methylated-DNA--[protein]-cysteine S-methyltransferase | - |
| HU731_RS28610 | 5141048..5141386 | - | 339 | WP_225931512.1 | hypothetical protein | - |
| HU731_RS23055 (HU731_023055) | 5141471..5141881 | - | 411 | WP_032893068.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| HU731_RS23060 (HU731_023060) | 5141903..5142085 | - | 183 | WP_003189411.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| HU731_RS23070 (HU731_023070) | 5142568..5143452 | - | 885 | WP_186605735.1 | alpha/beta hydrolase | - |
| HU731_RS23075 (HU731_023075) | 5143758..5144450 | - | 693 | WP_186605737.1 | pseudouridine synthase | - |
| HU731_RS23080 (HU731_023080) | 5144440..5144652 | - | 213 | WP_186605739.1 | cysteine-rich CWC family protein | - |
| HU731_RS23085 (HU731_023085) | 5144896..5145255 | + | 360 | WP_032892999.1 | hypothetical protein | - |
| HU731_RS23090 (HU731_023090) | 5145414..5145866 | + | 453 | WP_186605741.1 | DUF3757 domain-containing protein | - |
| HU731_RS23095 (HU731_023095) | 5145852..5146964 | - | 1113 | WP_186605743.1 | enoyl-CoA hydratase/isomerase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6804.01 Da Isoelectric Point: 10.7532
>T206677 WP_003189411.1 NZ_CP077083:c5142085-5141903 [Pseudomonas salmasensis]
VDSRYLIGHIVADGWYLVRIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS
VDSRYLIGHIVADGWYLVRIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS
Download Length: 183 bp
>T206677 NZ_CP102583:1020714-1020968 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14752.70 Da Isoelectric Point: 4.4574
>AT206677 WP_032893068.1 NZ_CP077083:c5141881-5141471 [Pseudomonas salmasensis]
MLYPIAISTGDADHAWGVEVPDIPGCYSAGEDLDDAMAMAREAIEGHFEILAEDGAPIPTAQKVTVHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLNHPQEKSRSGFLASAALKVLQQER
MLYPIAISTGDADHAWGVEVPDIPGCYSAGEDLDDAMAMAREAIEGHFEILAEDGAPIPTAQKVTVHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLNHPQEKSRSGFLASAALKVLQQER
Download Length: 411 bp
>AT206677 NZ_CP102583:1020470-1020712 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|