Detailed information of TA system TA206676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 5138006..5138519
• Replicon: chromosome
• Accession: NZ_CP077083
• Organism: Pseudomonas salmasensis strain SWRI126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HU731_RS23025
• Protein ID: WP_186605724.1
• Coordinates: 5138006..5138290 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HU731_RS23030
• Protein ID: WP_186605726.1
• Coordinates: 5138280..5138519 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU731_RS23005 (HU731_023005)	5134136..5135284	+	1149	WP_186605716.1	L-threonine dehydrogenase	-
HU731_RS23010 (HU731_023010)	5135893..5136567	+	675	WP_186605718.1	NAD(P)H-binding protein	-
HU731_RS23015 (HU731_023015)	5136539..5137015	-	477	WP_186605720.1	DMT family transporter	-
HU731_RS23020 (HU731_023020)	5137084..5137998	+	915	WP_186605722.1	LysR family transcriptional regulator	-
HU731_RS23025 (HU731_023025)	5138006..5138290	-	285	WP_186605724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU731_RS23030 (HU731_023030)	5138280..5138519	-	240	WP_186605726.1	ribbon-helix-helix protein, CopG family	Antitoxin
HU731_RS23035 (HU731_023035)	5138621..5139037	+	417	WP_186605728.1	fosfomycin resistance glutathione transferase	-
HU731_RS23040 (HU731_023040)	5139085..5139726	+	642	WP_186605731.1	LysE family translocator	-
HU731_RS23045 (HU731_023045)	5139846..5140373	+	528	WP_003189402.1	DUF4142 domain-containing protein	-
HU731_RS23050 (HU731_023050)	5140460..5140960	-	501	WP_186605733.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
HU731_RS28610	5141048..5141386	-	339	WP_225931512.1	hypothetical protein	-
HU731_RS23055 (HU731_023055)	5141471..5141881	-	411	WP_032893068.1	type II toxin-antitoxin system HicB family antitoxin	-
HU731_RS23060 (HU731_023060)	5141903..5142085	-	183	WP_003189411.1	type II toxin-antitoxin system HicA family toxin	-
HU731_RS23070 (HU731_023070)	5142568..5143452	-	885	WP_186605735.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10985.71 Da
• Isoelectric Point: 10.0857

>T206676 WP_186605724.1 NZ_CP077083:c5138290-5138006 [Pseudomonas salmasensis]
MQVEWLRAALRNLDDEAAYIAEENPKAAHEFVQAILSGLEQVAAFPAMGKEGRVPGTREWVVSRWPYIVPYRIREGRLQV
MRIFHTRRQPPKVW

Nucleotide

• Length: 285 bp

>T206676 NZ_CP102583:894424-894678 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8568.68 Da
• Isoelectric Point: 4.5881

>AT206676 WP_186605726.1 NZ_CP077083:c5138519-5138280 [Pseudomonas salmasensis]
MSVMSLRIPEDVADTLASLAKATGRSKSFLAVDALREYLAREAWQIEEIQKAVKEADAGDFATADEVKAVADKWRANAG

Nucleotide

• Length: 240 bp

>AT206676 NZ_CP102583:894166-894420 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA