Detailed information of TA system TA206675

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 3459902..3461610
• Replicon: chromosome
• Accession: NZ_CP077083
• Organism: Pseudomonas salmasensis strain SWRI126

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: HU731_RS15615
• Protein ID: WP_186607100.1
• Coordinates: 3459902..3460780 (+)
• Length: 293 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: HU731_RS15620
• Protein ID: WP_003195671.1
• Coordinates: 3460777..3461610 (+)
• Length: 278 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU731_RS15590 (HU731_015590)	3455908..3456744	+	837	WP_050499539.1	ABC transporter ATP-binding protein	-
HU731_RS15595 (HU731_015595)	3456784..3457776	+	993	WP_186607097.1	ABC transporter substrate-binding protein	-
HU731_RS15600 (HU731_015600)	3457804..3458580	+	777	WP_034134082.1	ABC transporter permease	-
HU731_RS15605 (HU731_015605)	3458577..3459344	+	768	WP_186607098.1	SDR family oxidoreductase	-
HU731_RS15610 (HU731_015610)	3459358..3459897	+	540	WP_186607099.1	cupin domain-containing protein	-
HU731_RS15615 (HU731_015615)	3459902..3460780	+	879	WP_186607100.1	alpha/beta hydrolase	Toxin
HU731_RS15620 (HU731_015620)	3460777..3461610	+	834	WP_003195671.1	IclR family transcriptional regulator	Antitoxin
HU731_RS15625 (HU731_015625)	3461612..3462409	+	798	WP_032894477.1	SDR family oxidoreductase	-
HU731_RS15630 (HU731_015630)	3462402..3464087	+	1686	WP_186607101.1	thiamine pyrophosphate-binding protein	-
HU731_RS15635 (HU731_015635)	3464098..3464901	+	804	WP_034134086.1	aspartate dehydrogenase	-
HU731_RS15640 (HU731_015640)	3464911..3466407	+	1497	WP_186607102.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (45-276)

Antitoxin

• Transcription regulator IclR, N-terminal (19-68)

Sequences

Toxin

Protein

• Length: 293 a.a.
• Molecular weight: 30816.28 Da
• Isoelectric Point: 7.6690

>T206675 WP_186607100.1 NZ_CP077083:3459902-3460780 [Pseudomonas salmasensis]
MLPGLSQAAPPADLQAQLERDFPQRLVASAGGQQALRECGAGPVVVLLHGIGSGAASWLQVARQLAPQARVIAWDAPGYG
DSSPLESDAPKAEQYAARLAQMLDALGVEECVLVGHSLGALTALAFARSSQAHRVNRLVLISPARGYGAPALGQQRQQVR
QQRLDNLQRLGIAGLAEQRSAHMLSPRATLQALAWVRWNMARLNPVGYRQAIELLCGDDLLRHGQPAMPCEVHCGEADSI
TPAEACLSVAKALGASFNLIADAGHASPIEQPQVVAGRLACAIHQSLTGRTL

Nucleotide

• Length: 879 bp

>T206675 NZ_CP102583:873115-873294 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 278 a.a.
• Molecular weight: 30601.10 Da
• Isoelectric Point: 6.9636

>AT206675 WP_003195671.1 NZ_CP077083:3460777-3461610 [Pseudomonas salmasensis]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRVNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVMALFDLVQADRQRGFVSGEGFFESAISTVAAPVRDQSGGIVAALGVTIPTAQIGHVNF
EELLNQVRRSADELSRLLNYNGGAHNGQPRVTALMRD

Nucleotide

• Length: 834 bp

>AT206675 NZ_CP102583:873331-873783 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATTAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA