Detailed information of TA system TA206674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2452502..2453007
• Replicon: chromosome
• Accession: NZ_CP077083
• Organism: Pseudomonas salmasensis strain SWRI126

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HU731_RS10800
• Protein ID: WP_135309690.1
• Coordinates: 2452753..2453007 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I4K3F7
• Locus tag: HU731_RS10795
• Protein ID: WP_003194039.1
• Coordinates: 2452502..2452756 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU731_RS10775 (HU731_010775)	2447665..2447838	+	174	WP_186607818.1	hypothetical protein	-
HU731_RS10780 (HU731_010780)	2447942..2449843	+	1902	WP_186607817.1	alkaline phosphatase D family protein	-
HU731_RS10785 (HU731_010785)	2449981..2450994	+	1014	WP_186607816.1	sensor domain-containing diguanylate cyclase	-
HU731_RS10790 (HU731_010790)	2451104..2452357	+	1254	WP_186607815.1	aspartate aminotransferase family protein	-
HU731_RS10795 (HU731_010795)	2452502..2452756	+	255	WP_003194039.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HU731_RS10800 (HU731_010800)	2452753..2453007	+	255	WP_135309690.1	Txe/YoeB family addiction module toxin	Toxin
HU731_RS10805 (HU731_010805)	2453108..2453824	+	717	WP_186607814.1	hypothetical protein	-
HU731_RS10810 (HU731_010810)	2453874..2455175	-	1302	WP_225931651.1	MFS transporter	-
HU731_RS10815 (HU731_010815)	2455249..2455920	-	672	WP_189661204.1	LuxR C-terminal-related transcriptional regulator	-
HU731_RS10820 (HU731_010820)	2456042..2457124	-	1083	WP_186607812.1	pyridoxal phosphate-dependent aminotransferase	-
HU731_RS10825 (HU731_010825)	2457337..2457942	+	606	WP_186607811.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10035.54 Da
• Isoelectric Point: 7.2753

>T206674 WP_135309690.1 NZ_CP077083:2452753-2453007 [Pseudomonas salmasensis]
MKILFTPEGWDDYLWFQQNDKAGLKRINLLIKAIQRDPFDGVGKPEPLKHNLSGFWSRRITAEHRLVYGIEDDEVQILMC
RYHY

Nucleotide

• Length: 255 bp

>T206674 NZ_CP102582:2762-3049 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9576.93 Da
• Isoelectric Point: 7.2034

>AT206674 WP_003194039.1 NZ_CP077083:2452502-2452756 [Pseudomonas salmasensis]
METINYTNARAHLSETMDRVNDDHVPLLLTRQKGEPVVMISLSEFNALEETAYLLRSPKNAERLINSVNSLRAGKAKPRR
LIEE

Nucleotide

• Length: 255 bp

>AT206674 NZ_CP102582:3036-3350 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0W0MVN5