Detailed information of TA system TA206671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 6183181..6183820
• Replicon: chromosome
• Accession: NZ_CP077082
• Organism: Pseudomonas sp. OE 28.3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU759_RS27910
• Protein ID: WP_170037068.1
• Coordinates: 6183629..6183820 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HU759_RS27905
• Protein ID: WP_099550415.1
• Coordinates: 6183181..6183582 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU759_RS27885 (HU759_027885)	6179648..6179971	-	324	WP_170036908.1	hypothetical protein	-
HU759_RS27890 (HU759_027890)	6180153..6180788	+	636	WP_170036905.1	helix-turn-helix domain-containing protein	-
HU759_RS27895 (HU759_027895)	6180820..6181485	-	666	WP_170036903.1	RES family NAD+ phosphorylase	-
HU759_RS29950	6181923..6182219	-	297	WP_225933014.1	hypothetical protein	-
HU759_RS27900 (HU759_027900)	6182225..6182470	-	246	WP_170036902.1	hypothetical protein	-
HU759_RS27905 (HU759_027905)	6183181..6183582	-	402	WP_099550415.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU759_RS27910 (HU759_027910)	6183629..6183820	-	192	WP_170037068.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU759_RS27915 (HU759_027915)	6184089..6184535	+	447	WP_058420501.1	Lrp/AsnC family transcriptional regulator	-
HU759_RS27920 (HU759_027920)	6184703..6186385	+	1683	WP_065929487.1	NAD(P)/FAD-dependent oxidoreductase	-
HU759_RS27925 (HU759_027925)	6186396..6187190	+	795	WP_017138045.1	carbon-nitrogen hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	6146455..6186385	39930

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7133.23 Da
• Isoelectric Point: 10.4871

>T206671 WP_170037068.1 NZ_CP077082:c6183820-6183629 [Pseudomonas sp. OE 28.3]
MRSREVIELLVEDGWFEVAVKGSHHQFKHPEKRGRVTVPHPKSEIAKGTLHSIFKSAGLNCRA

Nucleotide

• Length: 192 bp

>T206671 NZ_CP102554:c1443-1108 [Klebsiella pneumoniae]
ATGGAATACTACGAGTTTGTAGAAACCTCTGTGTTCACGCGAGAGATGAAAACTCTACTCAGTGATGATGAATACAAAGA
GTTTCAAACGTTCCTCATAGAGAACCCGGAGGCGGGTGATCTGATTGTAGGAACTGGCGGTTGTCGCAAGGTAAGATGGT
CACGGCAGGGAACAGGTAAAAGTTCAGGTGTCCGGGCTATTTACTACTTCTACAATCCAGCAGGCCGCTTATACATGCTT
ATCATCTATCCGAAGAGTGAGAAGGATAGTTTGACGGCAGCAGAGAAAAACCAGCTCAAAGCTGTTGTAGCGGGTTTTAA
AGGTGAAGAGGGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14621.40 Da
• Isoelectric Point: 4.5253

>AT206671 WP_099550415.1 NZ_CP077082:c6183582-6183181 [Pseudomonas sp. OE 28.3]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGASFSEALDNVREALALHLEGLVADEEKLPQAQEVDVHLDNPDYAGGVWAIV
DFDLTPYLGKSVRFNASLPEQLLHRIDERVQKDHRYASRSGFLATAALRELAV

Nucleotide

• Length: 402 bp

>AT206671 NZ_CP102554:c1103-813 [Klebsiella pneumoniae]
ATGCGTAAAGAGCTTTTTGATGATCTGATTGCTTCTGCTAAAGAAGCTGTAGAAATCCATCAGGGTTTACGTGAGCCAGC
TCGCGTGACCCGTTTTGAACGTCCAGATGTTAAAGCTATTCGGGCTAAGGTTCATATGAAACAAGATGATTTTGCCAGCC
TGATCGGGGTTAGCTCTTCTCTTGTTCAGTCATGGGAACAGGGGTTAAGAACTCCGGCAGGTGCAGCGTTAAAGCTGTTG
CGTGTCATCGAGCGTAAACCTGAATTTGTTCAGGAACTACGTGAAGCATAA