Detailed information of TA system TA206666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 3856049..3856662
• Replicon: chromosome
• Accession: NZ_CP077082
• Organism: Pseudomonas sp. OE 28.3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A554TDP9
• Locus tag: HU759_RS17110
• Protein ID: WP_017139593.1
• Coordinates: 3856049..3856312 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HU759_RS17115
• Protein ID: WP_170039686.1
• Coordinates: 3856297..3856662 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU759_RS17110 (HU759_017110)	3856049..3856312	+	264	WP_017139593.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU759_RS17115 (HU759_017115)	3856297..3856662	+	366	WP_170039686.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU759_RS17120 (HU759_017120)	3856629..3857834	-	1206	WP_170039688.1	MFS transporter	-
HU759_RS17125 (HU759_017125)	3857976..3858569	+	594	WP_138451557.1	TetR/AcrR family transcriptional regulator	-
HU759_RS17130 (HU759_017130)	3858553..3859908	-	1356	WP_186617727.1	MATE family efflux transporter	-
HU759_RS17135 (HU759_017135)	3859934..3860506	-	573	WP_169986371.1	DUF2239 family protein	-
HU759_RS17140 (HU759_017140)	3860755..3861585	-	831	WP_186617725.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10055.65 Da
• Isoelectric Point: 10.0954

>T206666 WP_017139593.1 NZ_CP077082:3856049-3856312 [Pseudomonas sp. OE 28.3]
VSKNEKLLAKLLNEHMAFTWPELVTLLHQLGYRQIEGAGSRVKFDIGNPSAMITLHRPHPGNELKHYIRRQIIEQLKSGE
LIQWTTN

Nucleotide

• Length: 264 bp

>T206666 NZ_CP102552:c4615823-4615290 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13205.09 Da
• Isoelectric Point: 6.3193

>AT206666 WP_170039686.1 NZ_CP077082:3856297-3856662 [Pseudomonas sp. OE 28.3]
VDNQLKHQGYIGSIEASLEDNCLFGKVLFIKALVSYEGKTVAELDAAFREAVDDYLVTCQALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHCVEPLPAVG

Nucleotide

• Length: 366 bp

>AT206666 NZ_CP102552:c4616100-4615834 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A554TDP9