Detailed information of TA system TA206665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1882291..1882807
• Replicon: chromosome
• Accession: NZ_CP077082
• Organism: Pseudomonas sp. OE 28.3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HU759_RS08475
• Protein ID: WP_170040570.1
• Coordinates: 1882291..1882578 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HU759_RS08480
• Protein ID: WP_026013721.1
• Coordinates: 1882568..1882807 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU759_RS08440 (HU759_008440)	1877580..1878458	+	879	WP_017137337.1	4-hydroxy-tetrahydrodipicolinate synthase	-
HU759_RS08445 (HU759_008445)	1878476..1879591	+	1116	WP_017137338.1	outer membrane protein assembly factor BamC	-
HU759_RS08450 (HU759_008450)	1879596..1880354	+	759	WP_170040571.1	MBL fold metallo-hydrolase	-
HU759_RS08455 (HU759_008455)	1880382..1881095	+	714	WP_017137340.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
HU759_RS08465 (HU759_008465)	1881388..1881783	+	396	WP_017137341.1	nucleotidyltransferase domain-containing protein	-
HU759_RS08470 (HU759_008470)	1881773..1882221	+	449	Protein_1669	DUF86 domain-containing protein	-
HU759_RS08475 (HU759_008475)	1882291..1882578	-	288	WP_170040570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU759_RS08480 (HU759_008480)	1882568..1882807	-	240	WP_026013721.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HU759_RS08485 (HU759_008485)	1883233..1884459	-	1227	WP_170040569.1	MFS transporter	-
HU759_RS08490 (HU759_008490)	1884854..1885726	-	873	WP_186617475.1	DUF6216 family protein	-
HU759_RS08495 (HU759_008495)	1886002..1886256	+	255	WP_017137348.1	hypothetical protein	-
HU759_RS08500 (HU759_008500)	1886400..1886951	+	552	WP_138451163.1	cytochrome b	-
HU759_RS08505 (HU759_008505)	1886992..1887543	+	552	WP_186617477.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-77)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-73)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11162.92 Da
• Isoelectric Point: 10.0984

>T206665 WP_170040570.1 NZ_CP077082:c1882578-1882291 [Pseudomonas sp. OE 28.3]
MTYSLDFDARALKEWQKLGDTIRQQLKKKLAAILNNPRIEANRLHDLPDCYKIKLRSSGYRLVYQVIDQEITVVVVAIDK
REREQAYRKAGERLS

Nucleotide

• Length: 288 bp

>T206665 NZ_CP102552:4003141-4003359 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8960.40 Da
• Isoelectric Point: 4.5881

>AT206665 WP_026013721.1 NZ_CP077082:c1882807-1882568 [Pseudomonas sp. OE 28.3]
MATISIRIDDDLKARAYLELEKLGVTPSELMRQALQYVADRGQLPFKPVLMTEEDEALMATVRERLASPQRVKVSIDDL

Nucleotide

• Length: 240 bp

>AT206665 NZ_CP102552:4002740-4003114 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG