Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1818571..1819175 Replicon chromosome
Accession NZ_CP077082
Organism Pseudomonas sp. OE 28.3

Toxin (Protein)


Gene name PumA Uniprot ID A0A554TIK1
Locus tag HU759_RS08175 Protein ID WP_026013719.1
Coordinates 1818882..1819175 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A7Y7V5U5
Locus tag HU759_RS08170 Protein ID WP_017137300.1
Coordinates 1818571..1818879 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU759_RS08140 (HU759_008140) 1814056..1814379 - 324 WP_017137294.1 hypothetical protein -
HU759_RS08145 (HU759_008145) 1814455..1814865 - 411 WP_186617453.1 type II toxin-antitoxin system HicB family antitoxin -
HU759_RS08150 (HU759_008150) 1814888..1815070 - 183 WP_017736377.1 type II toxin-antitoxin system HicA family toxin -
HU759_RS08155 (HU759_008155) 1815238..1816131 - 894 WP_099548620.1 LysR family transcriptional regulator -
HU759_RS08160 (HU759_008160) 1816227..1817390 + 1164 WP_017137298.1 MFS transporter -
HU759_RS08165 (HU759_008165) 1817387..1818586 + 1200 WP_186617455.1 MFS transporter -
HU759_RS08170 (HU759_008170) 1818571..1818879 - 309 WP_017137300.1 putative addiction module antidote protein Antitoxin
HU759_RS08175 (HU759_008175) 1818882..1819175 - 294 WP_026013719.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU759_RS08180 (HU759_008180) 1819640..1819879 + 240 WP_017137302.1 DUF6124 family protein -
HU759_RS08185 (HU759_008185) 1820125..1820427 + 303 WP_138451921.1 type II toxin-antitoxin system HigB family toxin -
HU759_RS08190 (HU759_008190) 1820431..1820802 + 372 WP_170040591.1 transcriptional regulator -
HU759_RS08195 (HU759_008195) 1821568..1823052 + 1485 WP_169867457.1 SIR2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1809928..1830611 20683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(3-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10786.47 Da        Isoelectric Point: 10.8545

>T206664 WP_026013719.1 NZ_CP077082:c1819175-1818882 [Pseudomonas sp. OE 28.3]
VRYSIQQTQAFTQWCSAIRDLRAKITIARRIERASVGNLGDFKVLGGGVSEMRIDVGAGYRVYFTLRGREVVILLAGGDK
SSQEADIRRAKKLAKEV

Download         Length: 294 bp

>T206664 NZ_CP102552:c2681271-2679949 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11066.57 Da        Isoelectric Point: 4.7914

>AT206664 WP_017137300.1 NZ_CP077082:c1818879-1818571 [Pseudomonas sp. OE 28.3]
MTQTLTTFDMAELLDSDEAISEYLSQVLADGDNEEFLRAVGYVAKARGMTKIATDAGVGRESLYKAFAPGAKPRFETVLK
VLHSLGIDLLARPGHTSNYSIV

Download         Length: 309 bp

>AT206664 NZ_CP102552:c2681537-2681271 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554TIK1

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y7V5U5

References