Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1814455..1815070 Replicon chromosome
Accession NZ_CP077082
Organism Pseudomonas sp. OE 28.3

Toxin (Protein)


Gene name hicA Uniprot ID A0A0W0I427
Locus tag HU759_RS08150 Protein ID WP_017736377.1
Coordinates 1814888..1815070 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HU759_RS08145 Protein ID WP_186617453.1
Coordinates 1814455..1814865 (-) Length 137 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU759_RS08100 (HU759_008100) 1809654..1809938 - 285 WP_017137286.1 type II toxin-antitoxin system RelE/ParE family toxin -
HU759_RS08105 (HU759_008105) 1809928..1810167 - 240 WP_017137287.1 ribbon-helix-helix protein, CopG family -
HU759_RS08110 (HU759_008110) 1810269..1810679 + 411 WP_017137288.1 fosfomycin resistance glutathione transferase -
HU759_RS08115 (HU759_008115) 1810734..1811375 + 642 WP_169985477.1 LysE family translocator -
HU759_RS08120 (HU759_008120) 1811495..1812022 + 528 WP_017137290.1 DUF4142 domain-containing protein -
HU759_RS08125 (HU759_008125) 1812077..1812502 - 426 WP_017137291.1 low affinity iron permease family protein -
HU759_RS08130 (HU759_008130) 1812684..1813466 + 783 WP_017137292.1 GNAT family N-acetyltransferase -
HU759_RS08135 (HU759_008135) 1813467..1813967 - 501 WP_017137293.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
HU759_RS08140 (HU759_008140) 1814056..1814379 - 324 WP_017137294.1 hypothetical protein -
HU759_RS08145 (HU759_008145) 1814455..1814865 - 411 WP_186617453.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HU759_RS08150 (HU759_008150) 1814888..1815070 - 183 WP_017736377.1 type II toxin-antitoxin system HicA family toxin Toxin
HU759_RS08155 (HU759_008155) 1815238..1816131 - 894 WP_099548620.1 LysR family transcriptional regulator -
HU759_RS08160 (HU759_008160) 1816227..1817390 + 1164 WP_017137298.1 MFS transporter -
HU759_RS08165 (HU759_008165) 1817387..1818586 + 1200 WP_186617455.1 MFS transporter -
HU759_RS08170 (HU759_008170) 1818571..1818879 - 309 WP_017137300.1 putative addiction module antidote protein -
HU759_RS08175 (HU759_008175) 1818882..1819175 - 294 WP_026013719.1 type II toxin-antitoxin system RelE/ParE family toxin -
HU759_RS08180 (HU759_008180) 1819640..1819879 + 240 WP_017137302.1 DUF6124 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1809928..1830611 20683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6791.96 Da        Isoelectric Point: 10.7532

>T206663 WP_017736377.1 NZ_CP077082:c1815070-1814888 [Pseudomonas sp. OE 28.3]
VDSRYLIGHIVADGWYLVRTRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS

Download         Length: 183 bp

>T206663 NZ_CP102552:1966113-1966215 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14886.79 Da        Isoelectric Point: 4.2835

>AT206663 WP_186617453.1 NZ_CP077082:c1814865-1814455 [Pseudomonas sp. OE 28.3]
MLYPIAISTGDEDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPTAQKVTLHAANPEYADCIWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQEH

Download         Length: 411 bp

>AT206663 NZ_CP102552:c1966222-1966077 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0W0I427


Antitoxin

Source ID Structure

References