Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1809654..1810167 Replicon chromosome
Accession NZ_CP077082
Organism Pseudomonas sp. OE 28.3

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y8E6S3
Locus tag HU759_RS08100 Protein ID WP_017137286.1
Coordinates 1809654..1809938 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5R8QRD9
Locus tag HU759_RS08105 Protein ID WP_017137287.1
Coordinates 1809928..1810167 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU759_RS08080 (HU759_008080) 1805839..1806780 + 942 WP_186617448.1 hydroxymethylglutaryl-CoA lyase -
HU759_RS08085 (HU759_008085) 1806840..1808171 + 1332 WP_186617449.1 MFS transporter -
HU759_RS08090 (HU759_008090) 1808172..1808660 - 489 WP_017137284.1 DMT family transporter -
HU759_RS08095 (HU759_008095) 1808729..1809646 + 918 WP_186617451.1 LysR family transcriptional regulator -
HU759_RS08100 (HU759_008100) 1809654..1809938 - 285 WP_017137286.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU759_RS08105 (HU759_008105) 1809928..1810167 - 240 WP_017137287.1 ribbon-helix-helix protein, CopG family Antitoxin
HU759_RS08110 (HU759_008110) 1810269..1810679 + 411 WP_017137288.1 fosfomycin resistance glutathione transferase -
HU759_RS08115 (HU759_008115) 1810734..1811375 + 642 WP_169985477.1 LysE family translocator -
HU759_RS08120 (HU759_008120) 1811495..1812022 + 528 WP_017137290.1 DUF4142 domain-containing protein -
HU759_RS08125 (HU759_008125) 1812077..1812502 - 426 WP_017137291.1 low affinity iron permease family protein -
HU759_RS08130 (HU759_008130) 1812684..1813466 + 783 WP_017137292.1 GNAT family N-acetyltransferase -
HU759_RS08135 (HU759_008135) 1813467..1813967 - 501 WP_017137293.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
HU759_RS08140 (HU759_008140) 1814056..1814379 - 324 WP_017137294.1 hypothetical protein -
HU759_RS08145 (HU759_008145) 1814455..1814865 - 411 WP_186617453.1 type II toxin-antitoxin system HicB family antitoxin -
HU759_RS08150 (HU759_008150) 1814888..1815070 - 183 WP_017736377.1 type II toxin-antitoxin system HicA family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-83)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10979.61 Da        Isoelectric Point: 8.5814

>T206662 WP_017137286.1 NZ_CP077082:c1809938-1809654 [Pseudomonas sp. OE 28.3]
MQVDWLRAALRNLDDEAAYIAEENPKAAHEFVQAILTGLEHVAEFPAMGKEGRVPGTREWVVPRWPYIVPYRIRDGRLQV
MRIFHTRRQPPASW

Download         Length: 285 bp

>T206662 NZ_CP102552:874535-874945 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8611.75 Da        Isoelectric Point: 4.7719

>AT206662 WP_017137287.1 NZ_CP077082:c1810167-1809928 [Pseudomonas sp. OE 28.3]
MSVMSLRIPEDVADTLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALKEADAGDFATAAEVKAVADKWRNNAG

Download         Length: 240 bp

>AT206662 NZ_CP102552:874288-874554 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8E6S3

Antitoxin

Source ID Structure
AlphaFold DB A0A5R8QRD9

References