Detailed information of TA system TA206661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1169567..1170108
• Replicon: chromosome
• Accession: NZ_CP077082
• Organism: Pseudomonas sp. OE 28.3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HU759_RS05145
• Protein ID: WP_080593787.1
• Coordinates: 1169833..1170108 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y8E9V1
• Locus tag: HU759_RS05140
• Protein ID: WP_017138296.1
• Coordinates: 1169567..1169833 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU759_RS05125 (HU759_005125)	1165541..1167826	-	2286	WP_170036241.1	TonB-dependent siderophore receptor	-
HU759_RS05130 (HU759_005130)	1168033..1168713	+	681	WP_170036244.1	Fe2+-dependent dioxygenase	-
HU759_RS05135 (HU759_005135)	1168716..1169501	+	786	WP_170036246.1	tetratricopeptide repeat protein	-
HU759_RS05140 (HU759_005140)	1169567..1169833	+	267	WP_017138296.1	ribbon-helix-helix domain-containing protein	Antitoxin
HU759_RS05145 (HU759_005145)	1169833..1170108	+	276	WP_080593787.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HU759_RS05150 (HU759_005150)	1170167..1171330	-	1164	WP_017138295.1	type III PLP-dependent enzyme	-
HU759_RS05155 (HU759_005155)	1171825..1172982	-	1158	WP_017138294.1	ABC transporter ATP-binding protein	-
HU759_RS05160 (HU759_005160)	1172979..1173632	-	654	WP_017138293.1	ABC transporter permease	-
HU759_RS05165 (HU759_005165)	1173644..1174540	-	897	WP_017138292.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10788.46 Da
• Isoelectric Point: 8.5620

>T206661 WP_080593787.1 NZ_CP077082:1169833-1170108 [Pseudomonas sp. OE 28.3]
MELKWTSKALSDLARLFDFLAVVNRMAAARTVQSLSQAPLSLLSNPRIGERVEEFEPRDVRRLLVGHYEMRYEIQESTLY
ILRLWHVREDR

Nucleotide

• Length: 276 bp

>T206661 NZ_CP102552:740407-740892 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9674.99 Da
• Isoelectric Point: 5.0322

>AT206661 WP_017138296.1 NZ_CP077082:1169567-1169833 [Pseudomonas sp. OE 28.3]
MGADTKVLTAHVPTALAQKVDQMAARMDRSRGWIVKQALADWVDMEEARSRLTREAMADVDAGRVIDQQAVQAWADSLST
DSPLPVPR

Nucleotide

• Length: 267 bp

>AT206661 NZ_CP102552:740117-740410 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7Y8E9V1