Detailed information of TA system TA206657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1750482..1751104
• Replicon: chromosome
• Accession: NZ_CP077081
• Organism: Pseudomonas atacamensis strain SWRI76

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KSS92_RS07715
• Protein ID: WP_217879473.1
• Coordinates: 1750925..1751104 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KSS92_RS07710
• Protein ID: WP_217879472.1
• Coordinates: 1750482..1750889 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSS92_RS07685 (KSS92_07685)	1746172..1747521	+	1350	WP_217879469.1	diguanylate cyclase	-
KSS92_RS07690 (KSS92_07690)	1747674..1748177	+	504	WP_217879470.1	DUF4142 domain-containing protein	-
KSS92_RS07695 (KSS92_07695)	1748340..1748750	-	411	WP_016771301.1	low affinity iron permease family protein	-
KSS92_RS07700 (KSS92_07700)	1748910..1749680	+	771	WP_217879471.1	trans-aconitate 2-methyltransferase	-
KSS92_RS07705 (KSS92_07705)	1750195..1750422	-	228	Protein_1527	transcriptional regulator	-
KSS92_RS07710 (KSS92_07710)	1750482..1750889	-	408	WP_217879472.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KSS92_RS07715 (KSS92_07715)	1750925..1751104	-	180	WP_217879473.1	type II toxin-antitoxin system HicA family toxin	Toxin
KSS92_RS07725 (KSS92_07725)	1751772..1752656	-	885	WP_076566363.1	alpha/beta hydrolase	-
KSS92_RS07730 (KSS92_07730)	1752973..1753665	-	693	WP_123442935.1	pseudouridine synthase	-
KSS92_RS07735 (KSS92_07735)	1753699..1753929	-	231	WP_016771293.1	cysteine-rich CWC family protein	-
KSS92_RS07740 (KSS92_07740)	1753922..1755409	-	1488	WP_024011977.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6707.99 Da
• Isoelectric Point: 11.8222

>T206657 WP_217879473.1 NZ_CP077081:c1751104-1750925 [Pseudomonas atacamensis]
VNSRFLIGQLVADGWFLVRIRGSHHHFKHPTKPGLVTVPHQKKDLLKKTAISILQQAML

Nucleotide

• Length: 180 bp

>T206657 NZ_CP102548:103412-103828 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14533.53 Da
• Isoelectric Point: 4.5785

>AT206657 WP_217879472.1 NZ_CP077081:c1750889-1750482 [Pseudomonas atacamensis]
MLYPIAISIGDEEHAWGVEVPDIPGCFSAGDDLDDAVAMAREAIEGHFEILAYDGAPIPSASKLSLHVANPQYAGCAWAV
VDIDVVKYLGKAQKLNITLPGHLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Nucleotide

• Length: 408 bp

>AT206657 NZ_CP102548:103185-103415 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA