Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1750482..1751104 Replicon chromosome
Accession NZ_CP077081
Organism Pseudomonas atacamensis strain SWRI76

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS92_RS07715 Protein ID WP_217879473.1
Coordinates 1750925..1751104 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS92_RS07710 Protein ID WP_217879472.1
Coordinates 1750482..1750889 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS92_RS07685 (KSS92_07685) 1746172..1747521 + 1350 WP_217879469.1 diguanylate cyclase -
KSS92_RS07690 (KSS92_07690) 1747674..1748177 + 504 WP_217879470.1 DUF4142 domain-containing protein -
KSS92_RS07695 (KSS92_07695) 1748340..1748750 - 411 WP_016771301.1 low affinity iron permease family protein -
KSS92_RS07700 (KSS92_07700) 1748910..1749680 + 771 WP_217879471.1 trans-aconitate 2-methyltransferase -
KSS92_RS07705 (KSS92_07705) 1750195..1750422 - 228 Protein_1527 transcriptional regulator -
KSS92_RS07710 (KSS92_07710) 1750482..1750889 - 408 WP_217879472.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS92_RS07715 (KSS92_07715) 1750925..1751104 - 180 WP_217879473.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS92_RS07725 (KSS92_07725) 1751772..1752656 - 885 WP_076566363.1 alpha/beta hydrolase -
KSS92_RS07730 (KSS92_07730) 1752973..1753665 - 693 WP_123442935.1 pseudouridine synthase -
KSS92_RS07735 (KSS92_07735) 1753699..1753929 - 231 WP_016771293.1 cysteine-rich CWC family protein -
KSS92_RS07740 (KSS92_07740) 1753922..1755409 - 1488 WP_024011977.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6707.99 Da        Isoelectric Point: 11.8222

>T206657 WP_217879473.1 NZ_CP077081:c1751104-1750925 [Pseudomonas atacamensis]
VNSRFLIGQLVADGWFLVRIRGSHHHFKHPTKPGLVTVPHQKKDLLKKTAISILQQAML

Download         Length: 180 bp

>T206657 NZ_CP102548:103412-103828 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14533.53 Da        Isoelectric Point: 4.5785

>AT206657 WP_217879472.1 NZ_CP077081:c1750889-1750482 [Pseudomonas atacamensis]
MLYPIAISIGDEEHAWGVEVPDIPGCFSAGDDLDDAVAMAREAIEGHFEILAYDGAPIPSASKLSLHVANPQYAGCAWAV
VDIDVVKYLGKAQKLNITLPGHLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT206657 NZ_CP102548:103185-103415 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References