Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 545334..545962 Replicon chromosome
Accession NZ_CP077081
Organism Pseudomonas atacamensis strain SWRI76

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KSS92_RS02395 Protein ID WP_016772140.1
Coordinates 545334..545732 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KSS92_RS02400 Protein ID WP_076565118.1
Coordinates 545732..545962 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS92_RS02375 (KSS92_02375) 541008..541703 - 696 WP_217879156.1 ABC transporter permease -
KSS92_RS02380 (KSS92_02380) 541781..542533 - 753 WP_217879157.1 ABC transporter substrate-binding protein -
KSS92_RS02385 (KSS92_02385) 542547..543320 - 774 WP_024011209.1 ABC transporter ATP-binding protein -
KSS92_RS02390 (KSS92_02390) 543864..545255 + 1392 WP_016772141.1 GABA permease -
KSS92_RS02395 (KSS92_02395) 545334..545732 - 399 WP_016772140.1 tRNA(fMet)-specific endonuclease VapC Toxin
KSS92_RS02400 (KSS92_02400) 545732..545962 - 231 WP_076565118.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KSS92_RS02405 (KSS92_02405) 546128..546580 - 453 WP_016772138.1 hypothetical protein -
KSS92_RS02410 (KSS92_02410) 546587..547000 - 414 WP_016772137.1 hypothetical protein -
KSS92_RS02415 (KSS92_02415) 547030..548004 - 975 WP_217879158.1 alpha/beta fold hydrolase -
KSS92_RS02420 (KSS92_02420) 548072..549130 - 1059 WP_136492691.1 PDDEXK nuclease domain-containing protein -
KSS92_RS02425 (KSS92_02425) 549412..549756 - 345 WP_110602162.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 537223..545962 8739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14547.92 Da        Isoelectric Point: 7.1340

>T206654 WP_016772140.1 NZ_CP077081:c545732-545334 [Pseudomonas atacamensis]
MIKYMLDTNICIFTIKNKPQIVREAFNRHSGQLCISAITLMELIYGAEKSAAPEKNLAIVEGFVARLDVLPFDNDAAAQA
GMVRSELAKAGTPIGPYDQMIAGHARSLGLIVVTNNVREFQRVSGLRIEDWV

Download         Length: 399 bp

>T206654 NZ_CP102548:c5488-5213 [Klebsiella pneumoniae]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8602.65 Da        Isoelectric Point: 4.5203

>AT206654 WP_076565118.1 NZ_CP077081:c545962-545732 [Pseudomonas atacamensis]
MEQTTIFMSNRSQAVRLPKAVAMPADVKRVEVIAIGRTRVITPAGESWDSWFDGDSVSPDFMANREQPTEQERESF

Download         Length: 231 bp

>AT206654 NZ_CP102548:c5772-5488 [Klebsiella pneumoniae]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References