Detailed information of TA system TA206652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4307338..4307885
• Replicon: chromosome
• Accession: NZ_CP077080
• Organism: Pseudomonas alvandae strain SWRI17

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KSS97_RS19000
• Protein ID: WP_198796045.1
• Coordinates: 4307610..4307885 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7V8RKA9
• Locus tag: KSS97_RS18995
• Protein ID: WP_030141313.1
• Coordinates: 4307338..4307610 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSS97_RS18985 (KSS97_18985)	4304081..4305613	+	1533	WP_217859903.1	NADH-quinone oxidoreductase subunit M	-
KSS97_RS18990 (KSS97_18990)	4305621..4307084	+	1464	WP_217859904.1	NADH-quinone oxidoreductase subunit NuoN	-
KSS97_RS18995 (KSS97_18995)	4307338..4307610	+	273	WP_030141313.1	ribbon-helix-helix domain-containing protein	Antitoxin
KSS97_RS19000 (KSS97_19000)	4307610..4307885	+	276	WP_198796045.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KSS97_RS19005 (KSS97_19005)	4307949..4309058	+	1110	WP_217859905.1	NAD(P)/FAD-dependent oxidoreductase	-
KSS97_RS19010 (KSS97_19010)	4309257..4309733	+	477	WP_030141310.1	hemerythrin domain-containing protein	-
KSS97_RS19015 (KSS97_19015)	4309787..4310665	-	879	WP_217859906.1	LysR family transcriptional regulator	-
KSS97_RS19020 (KSS97_19020)	4310913..4311542	-	630	WP_030141308.1	isochorismate family cysteine hydrolase YcaC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10658.21 Da
• Isoelectric Point: 8.5042

>T206652 WP_198796045.1 NZ_CP077080:4307610-4307885 [Pseudomonas alvandae]
MELKWTSKALSDIARLYEFLASVNQPAAARTVQQLTAAPSSLLVNPRIGERLEEFEPRDVRRIQVGHYEMRYEIVGSTLY
LLRLWHTREDR

Nucleotide

• Length: 276 bp

>T206652 NZ_CP102546:3990144-3990491 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10094.38 Da
• Isoelectric Point: 6.0723

>AT206652 WP_030141313.1 NZ_CP077080:4307338-4307610 [Pseudomonas alvandae]
MTTTAKTRSVTAHVPVHLAEKVDLMAERLERSRNWIVKQALSAWIDQEEERSRLTHEALADVDAGRVIDHQAVQAWADSL
STDAPLPVPR

Nucleotide

• Length: 273 bp

>AT206652 NZ_CP102546:3990491-3990784 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7V8RKA9