206650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 731261..731850 Replicon chromosome
Accession NZ_CP077080
Organism Pseudomonas alvandae strain SWRI17

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KSS97_RS03215 Protein ID WP_030140979.1
Coordinates 731261..731566 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KSS97_RS03220 Protein ID WP_030140978.1
Coordinates 731563..731850 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS97_RS03200 (KSS97_03200) 727775..728842 + 1068 WP_030140982.1 uroporphyrinogen decarboxylase -
KSS97_RS03205 (KSS97_03205) 728891..730165 - 1275 WP_217861077.1 MFS transporter -
KSS97_RS03210 (KSS97_03210) 730285..731202 + 918 WP_217861078.1 LysR family transcriptional regulator -
KSS97_RS03215 (KSS97_03215) 731261..731566 + 306 WP_030140979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSS97_RS03220 (KSS97_03220) 731563..731850 + 288 WP_030140978.1 putative addiction module antidote protein Antitoxin
KSS97_RS03225 (KSS97_03225) 731952..732932 - 981 WP_225936084.1 alpha/beta hydrolase -
KSS97_RS03230 (KSS97_03230) 733322..733840 + 519 WP_217861079.1 hypothetical protein -
KSS97_RS03235 (KSS97_03235) 733925..734176 - 252 WP_030140975.1 hypothetical protein -
KSS97_RS03240 (KSS97_03240) 734203..734448 - 246 Protein_639 DUF6124 family protein -
KSS97_RS03245 (KSS97_03245) 734892..735491 + 600 WP_217861081.1 helix-turn-helix transcriptional regulator -
KSS97_RS03250 (KSS97_03250) 735481..736359 + 879 WP_217861082.1 queuosine precursor transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11390.06 Da        Isoelectric Point: 10.2763

>T206650 WP_030140979.1 NZ_CP077080:731261-731566 [Pseudomonas alvandae]
MTEIIRSSTFSGWLSKLADSRARMRIQVRVDRMADGNLGDVKALGEGLSEARIDYGPGYRIYFMQQGRQLIILLCGGDKS
SQARDIKQARLIAKSWQEQNP

Download         Length: 306 bp

>T206650 NZ_CP102546:c3557626-3557243 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGAAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10385.72 Da        Isoelectric Point: 4.6286

>AT206650 WP_030140978.1 NZ_CP077080:731563-731850 [Pseudomonas alvandae]
MTEQFTRWDSAEYLKTEEDMANYLDACMDEAGDDPAFIAKALGTIARARGMTQVARDAGLSRENLYRALSGEGNPEFGTI
LKVVKALGLKLHAST

Download         Length: 288 bp

>AT206650 NZ_CP102546:c3557868-3557626 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References