Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1818861..1819467 Replicon chromosome
Accession NC_003106
Organism Sulfolobus tokodaii str. 7

Toxin (Protein)


Gene name vapC Uniprot ID Q96ZN1
Locus tag STK_RS10085 Protein ID WP_010979870.1
Coordinates 1819075..1819467 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A832TDA7
Locus tag STK_RS10080 Protein ID WP_052846657.1
Coordinates 1818861..1819085 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STK_RS10060 (ST1797) 1815287..1815715 - 429 WP_010979866.1 Zn-ribbon domain-containing OB-fold protein -
STK_RS10065 (ST1798) 1815712..1816209 - 498 WP_010979867.1 Zn-ribbon domain-containing OB-fold protein -
STK_RS10070 (ST1799) 1816221..1817396 - 1176 WP_010979868.1 thiolase domain-containing protein -
STK_RS10075 (ST1800) 1817396..1818505 - 1110 WP_010979869.1 thiolase domain-containing protein -
STK_RS10080 (STK_18005) 1818861..1819085 + 225 WP_052846657.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
STK_RS10085 (ST1801) 1819075..1819467 + 393 WP_010979870.1 type II toxin-antitoxin system VapC family toxin Toxin
STK_RS10090 (ST1802) 1819558..1820682 - 1125 WP_010979871.1 acyl-CoA dehydrogenase family protein -
STK_RS10095 (ST1803) 1820756..1822621 + 1866 WP_010979872.1 AMP-binding protein -
STK_RS10100 (ST1804) 1822618..1823433 + 816 WP_052846658.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(7-123)

Antitoxin

Post-segregation antitoxin CcdA

(5-56)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14958.64 Da        Isoelectric Point: 7.1957

>T20665 WP_010979870.1 NC_003106:1819075-1819467 [Sulfurisphaera tokodaii str. 7]
MRDEFLLDASALYPILNYIDKIDVAKIYIIPLAFYEVGNTIWKEYYLHKKIKDPIILSALFQKFMSKLKLLNSPPAEEVM
KFAIEKELTFYDAAYVYSAASHGLILVSEDKELIKKANALSLKDFISKLS

Download         Length: 393 bp

>T20665 NC_003106:1819075-1819467 [Sulfurisphaera tokodaii str. 7]
ATGAGAGATGAGTTTTTATTAGATGCTTCAGCATTATACCCTATACTTAACTACATAGATAAAATAGACGTTGCTAAGAT
TTATATAATTCCTCTAGCTTTTTACGAGGTGGGAAACACAATATGGAAGGAATACTATCTTCATAAAAAAATTAAGGATC
CAATCATATTATCTGCTCTCTTTCAGAAGTTTATGAGTAAGCTTAAACTCCTTAATAGCCCCCCAGCTGAAGAAGTAATG
AAGTTTGCAATAGAAAAAGAACTGACTTTTTACGATGCTGCATACGTTTATTCTGCTGCATCTCATGGACTAATCTTAGT
CTCAGAAGACAAAGAGTTAATAAAGAAGGCTAATGCACTCTCACTTAAAGATTTTATAAGCAAATTATCTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8904.21 Da        Isoelectric Point: 4.8619

>AT20665 WP_052846657.1 NC_003106:1818861-1819085 [Sulfurisphaera tokodaii str. 7]
MSTVISVRVRKELKEKAEELGINIREVVEKALEEAIREKEKEEIKETARKIKELMKDISEDEWITSIREDRYER

Download         Length: 225 bp

>AT20665 NC_003106:1818861-1819085 [Sulfurisphaera tokodaii str. 7]
ATGTCAACCGTAATAAGTGTAAGAGTGAGGAAAGAGTTGAAGGAGAAAGCTGAAGAATTGGGAATAAACATTAGGGAGGT
TGTAGAGAAAGCTTTAGAGGAAGCAATACGAGAGAAAGAAAAGGAAGAAATCAAGGAAACTGCTAGGAAAATTAAGGAAC
TAATGAAGGATATTAGTGAGGATGAATGGATTACCTCAATAAGGGAAGATAGATATGAGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A832TGJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A832TDA7

References