Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 606416..607062 Replicon chromosome
Accession NZ_CP077080
Organism Pseudomonas alvandae strain SWRI17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KSS97_RS02670 Protein ID WP_030141494.1
Coordinates 606416..606832 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KSS97_RS02675 Protein ID WP_217861042.1
Coordinates 606832..607062 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS97_RS02645 (KSS97_02645) 601841..603070 - 1230 WP_217861040.1 methyltransferase -
KSS97_RS02650 (KSS97_02650) 603051..603740 - 690 WP_030141498.1 ABC transporter permease -
KSS97_RS02655 (KSS97_02655) 603737..604432 - 696 WP_198797081.1 ABC transporter permease -
KSS97_RS02660 (KSS97_02660) 604512..605267 - 756 WP_030141496.1 ABC transporter substrate-binding protein -
KSS97_RS02665 (KSS97_02665) 605281..606054 - 774 WP_217861041.1 ABC transporter ATP-binding protein -
KSS97_RS02670 (KSS97_02670) 606416..606832 - 417 WP_030141494.1 tRNA(fMet)-specific endonuclease VapC Toxin
KSS97_RS02675 (KSS97_02675) 606832..607062 - 231 WP_217861042.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KSS97_RS02680 (KSS97_02680) 607238..607687 + 450 WP_217861043.1 carboxypeptidase regulatory-like domain-containing protein -
KSS97_RS02685 (KSS97_02685) 607697..608143 - 447 WP_030141491.1 hypothetical protein -
KSS97_RS02690 (KSS97_02690) 608184..610418 - 2235 WP_217861044.1 ATP-binding protein -
KSS97_RS02695 (KSS97_02695) 610415..611020 - 606 WP_217861045.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 598368..607062 8694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15291.03 Da        Isoelectric Point: 8.2836

>T206649 WP_030141494.1 NZ_CP077080:c606832-606416 [Pseudomonas alvandae]
MIKFMLDTNICVFTIKNKPQVVREAFIRHHGQLCISAVTLMELIYGAEKSSAPEKNLSVIEGFCARLEVLPFGYDAAAHT
GMIRAELAKIGKPIGPYDQMIAGHARSLGLIVVTNNLKEFERVPGLRVEDWTPLALKP

Download         Length: 417 bp

>T206649 NZ_CP102546:c3239788-3238871 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8503.52 Da        Isoelectric Point: 4.3719

>AT206649 WP_217861042.1 NZ_CP077080:c607062-606832 [Pseudomonas alvandae]
MEQTTIFMSNRSQAVRLPKAVAMPSDVKRVDVIAIGRARIITPAGEAWDSWFDGDSATADFMAEREQPADQERESF

Download         Length: 231 bp

>AT206649 NZ_CP102546:c3240552-3239794 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAAGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References