Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2792643..2793256 Replicon chromosome
Accession NZ_CP077079
Organism Pseudomonas asgharzadehiana strain SWRI132

Toxin (Protein)


Gene name hicA Uniprot ID A0A2H2Z6Z3
Locus tag KSS96_RS12860 Protein ID WP_065877936.1
Coordinates 2793005..2793256 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2H2YCW8
Locus tag KSS96_RS12855 Protein ID WP_065877934.1
Coordinates 2792643..2793008 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS96_RS12835 (KSS96_12835) 2787855..2789072 + 1218 WP_017530276.1 nicotinate phosphoribosyltransferase -
KSS96_RS12840 (KSS96_12840) 2789074..2789880 + 807 WP_017530277.1 ammonia-dependent NAD(+) synthetase -
KSS96_RS12845 (KSS96_12845) 2790074..2791429 + 1356 WP_065877943.1 MATE family efflux transporter -
KSS96_RS12850 (KSS96_12850) 2791470..2792642 + 1173 WP_065877933.1 MFS transporter -
KSS96_RS12855 (KSS96_12855) 2792643..2793008 - 366 WP_065877934.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS96_RS12860 (KSS96_12860) 2793005..2793256 - 252 WP_065877936.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9627.19 Da        Isoelectric Point: 10.4537

>T206648 WP_065877936.1 NZ_CP077079:c2793256-2793005 [Pseudomonas asgharzadehiana]
VSKNEKLLAKLLNEQTLFTWPEWVTLLRRLGYTQIEGAGSRVKFDIGNPSAMITLHRPHPGNELKHYIRRQIIEHLRSGE
LIP

Download         Length: 252 bp

>T206648 NZ_CP102546:c3079561-3079277 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13079.86 Da        Isoelectric Point: 6.7447

>AT206648 WP_065877934.1 NZ_CP077079:c2793008-2792643 [Pseudomonas asgharzadehiana]
VNNQLKYKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFHEAVDDYLATCQSLGQTPEKPCKGSFNVRVGH
ELHLAAALAAARKKVTLNDLTRQALNEFLHHHSADAGPAIG

Download         Length: 366 bp

>AT206648 NZ_CP102546:c3079793-3079551 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H2Z6Z3

Antitoxin

Source ID Structure
AlphaFold DB A0A2H2YCW8

References