Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 526892..527594 Replicon chromosome
Accession NZ_CP077079
Organism Pseudomonas asgharzadehiana strain SWRI132

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS96_RS02425 Protein ID WP_217855686.1
Coordinates 527412..527594 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS96_RS02420 Protein ID WP_217855684.1
Coordinates 526892..527332 (-) Length 147 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS96_RS02395 (KSS96_02395) 523128..523703 + 576 WP_217855678.1 hypothetical protein -
KSS96_RS02400 (KSS96_02400) 523724..524626 + 903 WP_217856441.1 hypothetical protein -
KSS96_RS02405 (KSS96_02405) 524623..525165 + 543 WP_217855679.1 DNA-binding protein -
KSS96_RS02410 (KSS96_02410) 525162..525866 + 705 WP_217855680.1 hypothetical protein -
KSS96_RS02415 (KSS96_02415) 525839..526813 + 975 WP_217855682.1 hypothetical protein -
KSS96_RS02420 (KSS96_02420) 526892..527332 - 441 WP_217855684.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS96_RS02425 (KSS96_02425) 527412..527594 - 183 WP_217855686.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS96_RS02430 (KSS96_02430) 528133..528492 - 360 WP_217855688.1 hypothetical protein -
KSS96_RS02435 (KSS96_02435) 529038..529481 - 444 WP_225913308.1 hypothetical protein -
KSS96_RS02440 (KSS96_02440) 529484..529990 - 507 WP_217855692.1 hypothetical protein -
KSS96_RS02450 (KSS96_02450) 530315..531691 - 1377 WP_026067116.1 HlyD family type I secretion periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 483910..533834 49924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.87 Da        Isoelectric Point: 11.2210

>T206645 WP_217855686.1 NZ_CP077079:c527594-527412 [Pseudomonas asgharzadehiana]
MQSREVIKRLIDDGWVKVKGGDGSHQQFKHPTKKGRVTVPHPQKDVPLGTLRSIWKQAGL

Download         Length: 183 bp

>T206645 NZ_CP102546:c984606-983284 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 147 a.a.        Molecular weight: 16188.07 Da        Isoelectric Point: 4.4720

>AT206645 WP_217855684.1 NZ_CP077079:c527332-526892 [Pseudomonas asgharzadehiana]
MKYVVVLHKDEGSDYGVTVPDVPGCFSAGETIDEALRNVVDALSMQFEGLVEDGEPMPEAQSIEHHRKDPDYADGIWAFV
EFDTTPYYGKAVRFNASLPEGLLKKIDDRVKEGNSYASRSGFLATAALHELAKYLEEDVKSRRVAS

Download         Length: 441 bp

>AT206645 NZ_CP102546:c984872-984606 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References