Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/HTH_10(toxin) |
| Location | 1589808..1590783 | Replicon | chromosome |
| Accession | NC_003106 | ||
| Organism | Sulfolobus tokodaii str. 7 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q970K2 |
| Locus tag | STK_RS08905 | Protein ID | WP_010979649.1 |
| Coordinates | 1589808..1590422 (-) | Length | 205 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A832WQV7 |
| Locus tag | STK_RS08910 | Protein ID | WP_052846979.1 |
| Coordinates | 1590436..1590783 (-) | Length | 116 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STK_RS08885 (ST1590) | 1585040..1586098 | + | 1059 | WP_010979645.1 | hypothetical protein | - |
| STK_RS08890 (ST1591) | 1586112..1587566 | + | 1455 | WP_010979646.1 | 4Fe-4S binding protein | - |
| STK_RS08895 (STK_15915) | 1587947..1588204 | - | 258 | WP_010979647.1 | DUF4898 domain-containing protein | - |
| STK_RS08900 (ST1592) | 1588546..1589583 | - | 1038 | WP_010979648.1 | hypothetical protein | - |
| STK_RS08905 (ST1593) | 1589808..1590422 | - | 615 | WP_010979649.1 | helix-turn-helix domain-containing protein | Toxin |
| STK_RS08910 (ST1594) | 1590436..1590783 | - | 348 | WP_052846979.1 | DUF488 domain-containing protein | Antitoxin |
| STK_RS08915 (ST1595) | 1591184..1591627 | - | 444 | WP_010979651.1 | hypothetical protein | - |
| STK_RS08920 (ST1596) | 1591856..1592710 | + | 855 | WP_010979652.1 | amidohydrolase family protein | - |
| STK_RS08925 (ST1597) | 1592977..1594107 | - | 1131 | WP_010979653.1 | hypothetical protein | - |
| STK_RS14900 | 1594418..1594564 | + | 147 | Protein_1816 | ISNCY family transposase | - |
| STK_RS08930 (STK_15974) | 1594621..1594845 | - | 225 | Protein_1817 | IS110 family transposase | - |
| STK_RS08935 | 1595371..1595568 | - | 198 | WP_052846606.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 205 a.a. Molecular weight: 23087.00 Da Isoelectric Point: 9.2970
>T20664 WP_010979649.1 NC_003106:c1590422-1589808 [Sulfurisphaera tokodaii str. 7]
MPKSPFEVTLLIEDHPCEVMKLISTMGLKASVENVKLGDNVTDHIVLFDNKVKNEDVLKLKSGNSKVLRLSDNRIWVRTN
GCSVCKVLYTSDVVVEKIKVVKERTLLYTLLIPNTSSLKEFLSKLTSQGVKVTVISTNEITGNELTERQMEILKLAYRLG
YFDDDRGITLTELANRLNVSAPTLEEILRRALRKVVKYYLDKVG
MPKSPFEVTLLIEDHPCEVMKLISTMGLKASVENVKLGDNVTDHIVLFDNKVKNEDVLKLKSGNSKVLRLSDNRIWVRTN
GCSVCKVLYTSDVVVEKIKVVKERTLLYTLLIPNTSSLKEFLSKLTSQGVKVTVISTNEITGNELTERQMEILKLAYRLG
YFDDDRGITLTELANRLNVSAPTLEEILRRALRKVVKYYLDKVG
Download Length: 615 bp
>T20664 NC_003106:c1590422-1589808 [Sulfurisphaera tokodaii str. 7]
ATGCCTAAATCACCGTTTGAAGTTACTCTATTGATAGAGGATCATCCTTGTGAGGTAATGAAGCTTATATCTACTATGGG
CCTAAAAGCAAGCGTAGAGAATGTTAAACTAGGAGATAATGTAACTGATCATATAGTATTATTCGATAACAAAGTTAAAA
ATGAAGATGTGTTAAAACTTAAATCGGGTAATAGTAAGGTATTAAGGCTCTCAGATAACAGAATATGGGTTAGAACAAAT
GGTTGTTCTGTATGTAAAGTGCTTTATACCTCTGACGTTGTTGTAGAAAAGATAAAAGTTGTTAAAGAGAGAACTTTACT
TTATACTCTCTTAATTCCTAATACTTCCTCATTAAAGGAGTTTTTATCAAAGCTAACAAGTCAAGGAGTTAAGGTTACTG
TAATAAGTACAAACGAGATAACTGGTAACGAGTTGACTGAGAGACAGATGGAAATATTAAAATTGGCTTATAGATTAGGG
TACTTTGATGATGATAGAGGCATAACTTTAACCGAATTGGCTAATAGATTGAACGTTTCTGCACCAACTCTGGAAGAAAT
ATTACGGAGAGCTTTAAGAAAAGTAGTTAAATACTATCTTGATAAAGTAGGATAA
ATGCCTAAATCACCGTTTGAAGTTACTCTATTGATAGAGGATCATCCTTGTGAGGTAATGAAGCTTATATCTACTATGGG
CCTAAAAGCAAGCGTAGAGAATGTTAAACTAGGAGATAATGTAACTGATCATATAGTATTATTCGATAACAAAGTTAAAA
ATGAAGATGTGTTAAAACTTAAATCGGGTAATAGTAAGGTATTAAGGCTCTCAGATAACAGAATATGGGTTAGAACAAAT
GGTTGTTCTGTATGTAAAGTGCTTTATACCTCTGACGTTGTTGTAGAAAAGATAAAAGTTGTTAAAGAGAGAACTTTACT
TTATACTCTCTTAATTCCTAATACTTCCTCATTAAAGGAGTTTTTATCAAAGCTAACAAGTCAAGGAGTTAAGGTTACTG
TAATAAGTACAAACGAGATAACTGGTAACGAGTTGACTGAGAGACAGATGGAAATATTAAAATTGGCTTATAGATTAGGG
TACTTTGATGATGATAGAGGCATAACTTTAACCGAATTGGCTAATAGATTGAACGTTTCTGCACCAACTCTGGAAGAAAT
ATTACGGAGAGCTTTAAGAAAAGTAGTTAAATACTATCTTGATAAAGTAGGATAA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13736.01 Da Isoelectric Point: 9.9648
>AT20664 WP_052846979.1 NC_003106:c1590783-1590436 [Sulfurisphaera tokodaii str. 7]
MLKIKRIYDPVEKDDGIRILVDRLWPRGVRKDKVDVWLKDIAPSDELRTWFNHDPNKWEEFKKKYFEELSKNPKLDILLQ
LIKKGENVTLLYTSKSPYNNAVALKEFLDKIFKAS
MLKIKRIYDPVEKDDGIRILVDRLWPRGVRKDKVDVWLKDIAPSDELRTWFNHDPNKWEEFKKKYFEELSKNPKLDILLQ
LIKKGENVTLLYTSKSPYNNAVALKEFLDKIFKAS
Download Length: 348 bp
>AT20664 NC_003106:c1590783-1590436 [Sulfurisphaera tokodaii str. 7]
ATGTTAAAAATAAAGAGAATTTATGATCCAGTAGAAAAAGATGACGGGATTAGGATATTGGTTGATAGATTATGGCCTAG
AGGTGTTAGGAAAGATAAGGTAGATGTATGGCTTAAAGATATAGCGCCTAGCGATGAATTAAGAACATGGTTTAATCATG
ATCCTAATAAGTGGGAAGAGTTTAAAAAGAAATATTTTGAAGAACTTAGTAAGAATCCTAAACTGGATATTTTATTACAG
TTGATTAAAAAAGGGGAAAATGTGACTCTACTTTATACATCTAAATCACCATATAATAATGCTGTAGCATTAAAGGAATT
TCTAGATAAGATATTTAAAGCGAGTTGA
ATGTTAAAAATAAAGAGAATTTATGATCCAGTAGAAAAAGATGACGGGATTAGGATATTGGTTGATAGATTATGGCCTAG
AGGTGTTAGGAAAGATAAGGTAGATGTATGGCTTAAAGATATAGCGCCTAGCGATGAATTAAGAACATGGTTTAATCATG
ATCCTAATAAGTGGGAAGAGTTTAAAAAGAAATATTTTGAAGAACTTAGTAAGAATCCTAAACTGGATATTTTATTACAG
TTGATTAAAAAAGGGGAAAATGTGACTCTACTTTATACATCTAAATCACCATATAATAATGCTGTAGCATTAAAGGAATT
TCTAGATAAGATATTTAAAGCGAGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A832TIR3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A832WQV7 |