Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5330293..5330939 Replicon chromosome
Accession NZ_CP077076
Organism Pseudomonas fakonensis strain COW40

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS94_RS23520 Protein ID WP_217840434.1
Coordinates 5330757..5330939 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS94_RS23515 Protein ID WP_217840433.1
Coordinates 5330293..5330700 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS94_RS23490 (KSS94_23490) 5326346..5327242 - 897 WP_217840428.1 LysR family transcriptional regulator -
KSS94_RS23495 (KSS94_23495) 5327364..5327954 - 591 WP_217840429.1 NAD(P)H-dependent oxidoreductase -
KSS94_RS23500 (KSS94_23500) 5328117..5328431 + 315 WP_217840430.1 putative quinol monooxygenase -
KSS94_RS23505 (KSS94_23505) 5328421..5329185 - 765 WP_217840431.1 sulfite exporter TauE/SafE family protein -
KSS94_RS23510 (KSS94_23510) 5329263..5330153 + 891 WP_217840432.1 LysR substrate-binding domain-containing protein -
KSS94_RS23515 (KSS94_23515) 5330293..5330700 - 408 WP_217840433.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS94_RS23520 (KSS94_23520) 5330757..5330939 - 183 WP_217840434.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS94_RS23525 (KSS94_23525) 5331153..5331758 + 606 WP_217840435.1 CDP-alcohol phosphatidyltransferase family protein -
KSS94_RS23530 (KSS94_23530) 5331788..5333542 + 1755 WP_217840436.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
KSS94_RS23535 (KSS94_23535) 5333542..5334873 + 1332 WP_217840437.1 phosphatase PAP2/dual specificity phosphatase family protein -
KSS94_RS23540 (KSS94_23540) 5334870..5335289 + 420 WP_217840438.1 hypothetical protein -
KSS94_RS23545 (KSS94_23545) 5335300..5335923 + 624 WP_217840439.1 lysophospholipid acyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6914.04 Da        Isoelectric Point: 10.8185

>T206639 WP_217840434.1 NZ_CP077076:c5330939-5330757 [Pseudomonas fakonensis]
MRSREVIQLIEANGWYEVDVKGSHHQFRHPFKKGRVTVPHPKCDLPRGTVHSILKQAGLK

Download         Length: 183 bp

>T206639 NZ_CP102541:c2177644-2177417 [Bifidobacterium longum subsp. infantis]
ATGAAGAAGCTGGATCGTAATGTTGCCAAGAGAATCATCGCAAAGCTTAGGGAAATTTCACAGTTGGAAGATCCGAGAAG
CACCGGCAAGGCTCTTGCCGGTAATCTGGCAGGGCTGTGGCGTTACCGTGTCGGGGACTATCGTATCGTGTGCGATATAG
AGGATGAGGTTCTGCTGATTCTTGTGATTGATGTCGCGCACAGGAGCAAGGTGTACAAGCGTTGCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14555.43 Da        Isoelectric Point: 4.7269

>AT206639 WP_217840433.1 NZ_CP077076:c5330700-5330293 [Pseudomonas fakonensis]
MKFPVVLHKDAGSDYGVTVPDVPGCFSAGATVSQALENVQEALALHFEGLVADGEPLPQAEEVDVHVLNPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAH

Download         Length: 408 bp

>AT206639 NZ_CP102541:c2177906-2177670 [Bifidobacterium longum subsp. infantis]
ATGGCCACGGTTACTGCAGCATTAAGGATGCCTGTCGAATTGGCGGCTCGTTACGATTGTCTGGCGAAAGCGACTGGTCG
TACGAAGACGTTTTACATGAACGAAGCCCTTACCGAATCGATCGATAGGTTTGAGTATGAATACGGCATTATGAAAAAGG
TCGAGGATTGGCGTGCCGGCAGACTCGAAACCGTGACGCTCGACGAGCTGGAGGAAAGCCTTGGCTTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References