Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 351906..352528 Replicon chromosome
Accession NZ_CP077076
Organism Pseudomonas fakonensis strain COW40

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS94_RS01495 Protein ID WP_217841350.1
Coordinates 351906..352097 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS94_RS01500 Protein ID WP_217841351.1
Coordinates 352115..352528 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS94_RS01465 (KSS94_01465) 347709..348122 + 414 WP_217841344.1 hypothetical protein -
KSS94_RS01470 (KSS94_01470) 348164..349090 + 927 WP_217841345.1 NAD synthetase -
KSS94_RS01475 (KSS94_01475) 349087..349515 + 429 WP_217841346.1 hypothetical protein -
KSS94_RS01480 (KSS94_01480) 349592..350029 + 438 WP_217841347.1 hypothetical protein -
KSS94_RS01485 (KSS94_01485) 350263..350529 - 267 WP_217841348.1 DUF3077 domain-containing protein -
KSS94_RS01490 (KSS94_01490) 350531..350806 - 276 WP_217841349.1 hypothetical protein -
KSS94_RS01495 (KSS94_01495) 351906..352097 + 192 WP_217841350.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS94_RS01500 (KSS94_01500) 352115..352528 + 414 WP_217841351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS94_RS01505 (KSS94_01505) 352636..354018 - 1383 WP_217841352.1 ATP-binding protein -
KSS94_RS01510 (KSS94_01510) 354020..354739 - 720 WP_217841353.1 response regulator transcription factor -
KSS94_RS01515 (KSS94_01515) 354895..357174 + 2280 WP_217841354.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 348164..368633 20469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7086.22 Da        Isoelectric Point: 11.0014

>T206637 WP_217841350.1 NZ_CP077076:351906-352097 [Pseudomonas fakonensis]
MNSREMISVIEADGWYLVRSKGSHHHFKHRHKPGLVTIPHPKKDLLAATAASILRQARIGYAS

Download         Length: 192 bp

>T206637 NZ_CP102541:1594539-1594895 [Bifidobacterium longum subsp. infantis]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCATCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGATGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14977.01 Da        Isoelectric Point: 4.6008

>AT206637 WP_217841351.1 NZ_CP077076:352115-352528 [Pseudomonas fakonensis]
MLFPIAILAGDDQHAWGVEVPDIPGCFSAGEDLDHAIAMAREAIEGHLELLAQDQQEIPKASTVTVHAANPDYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDCK

Download         Length: 414 bp

>AT206637 NZ_CP102541:1594256-1594552 [Bifidobacterium longum subsp. infantis]
ATGATGGCTATCAAGGAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCAT
GGGGTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCG
TCCGCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCC
CAGATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References