Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5900094..5900740 Replicon chromosome
Accession NZ_CP077075
Organism Pseudomonas xanthosomae strain COR54

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS93_RS26055 Protein ID WP_217886594.1
Coordinates 5900558..5900740 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS93_RS26050 Protein ID WP_217886593.1
Coordinates 5900094..5900501 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS93_RS26025 (KSS93_26025) 5896224..5897120 - 897 WP_217886588.1 LysR family transcriptional regulator -
KSS93_RS26030 (KSS93_26030) 5897241..5897831 - 591 WP_217886589.1 NAD(P)H-dependent oxidoreductase -
KSS93_RS26035 (KSS93_26035) 5897994..5898302 + 309 WP_217886590.1 putative quinol monooxygenase -
KSS93_RS26040 (KSS93_26040) 5898292..5899056 - 765 WP_217886591.1 sulfite exporter TauE/SafE family protein -
KSS93_RS26045 (KSS93_26045) 5899134..5900024 + 891 WP_217886592.1 LysR family transcriptional regulator -
KSS93_RS26050 (KSS93_26050) 5900094..5900501 - 408 WP_217886593.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS93_RS26055 (KSS93_26055) 5900558..5900740 - 183 WP_217886594.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS93_RS26060 (KSS93_26060) 5900954..5901559 + 606 WP_217886595.1 CDP-alcohol phosphatidyltransferase family protein -
KSS93_RS26065 (KSS93_26065) 5901590..5903344 + 1755 WP_217886596.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
KSS93_RS26070 (KSS93_26070) 5903344..5904684 + 1341 WP_217886597.1 phosphatase PAP2/dual specificity phosphatase family protein -
KSS93_RS26075 (KSS93_26075) 5904681..5905100 + 420 WP_217886598.1 hypothetical protein -
KSS93_RS26080 (KSS93_26080) 5905111..5905734 + 624 WP_217886599.1 lysophospholipid acyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6915.02 Da        Isoelectric Point: 10.5650

>T206636 WP_217886594.1 NZ_CP077075:c5900740-5900558 [Pseudomonas xanthosomae]
MRSREVIQLIEADGWYEVDVKGSHHQFRHPFKKGRVTVPHPKCDLPRGTVHSILKQAGLK

Download         Length: 183 bp

>T206636 NZ_CP102541:1132149-1132640 [Bifidobacterium longum subsp. infantis]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCAGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14554.44 Da        Isoelectric Point: 4.8836

>AT206636 WP_217886593.1 NZ_CP077075:c5900501-5900094 [Pseudomonas xanthosomae]
MKFPVVLHKDAGSDYGVTVPDVPGCFSAGATVSQALENVQQALALHFEGLVADGEPLPQAEEVDVHVLNPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAH

Download         Length: 408 bp

>AT206636 NZ_CP102541:1131787-1132149 [Bifidobacterium longum subsp. infantis]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTATACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATTTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAGCTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References