Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 816489..817092 Replicon chromosome
Accession NC_003106
Organism Sulfolobus tokodaii str. 7

Toxin (Protein)


Gene name vapC Uniprot ID Q973Q8
Locus tag STK_RS04675 Protein ID WP_010978835.1
Coordinates 816691..817092 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q973Q9
Locus tag STK_RS04670 Protein ID WP_010978834.1
Coordinates 816489..816710 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STK_RS04640 (ST0834) 812492..813214 + 723 WP_010978829.1 hypothetical protein -
STK_RS04645 (ST0835) 813417..813914 + 498 WP_052846425.1 DUF2258 domain-containing protein -
STK_RS04650 (ST0836) 813943..814878 + 936 WP_010978831.1 zinc metalloprotease HtpX -
STK_RS04655 (STK_08365) 814875..815162 - 288 WP_052846426.1 hypothetical protein -
STK_RS04660 (ST0837) 815198..815569 - 372 WP_010978832.1 helix-turn-helix domain-containing protein -
STK_RS04665 (ST0838) 815638..816306 - 669 WP_198429742.1 RAD55 family ATPase -
STK_RS04670 (STK_08385) 816489..816710 + 222 WP_010978834.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
STK_RS04675 (ST0839) 816691..817092 + 402 WP_010978835.1 PIN domain-containing protein Toxin
STK_RS04680 (ST0840) 817182..818150 - 969 WP_052846427.1 ABC transporter substrate-binding protein -
STK_RS04685 (ST0841) 818239..819216 + 978 WP_010978837.1 iron ABC transporter permease -
STK_RS04690 (ST0842) 819191..819850 + 660 WP_010978838.1 ABC transporter ATP-binding protein -
STK_RS04695 (ST0843) 819920..820246 + 327 WP_010978839.1 transcriptional regulator -
STK_RS04700 (ST0844) 820284..821192 + 909 WP_010978840.1 mechanosensitive ion channel family protein -
STK_RS04705 (ST0845) 821170..821607 + 438 WP_010978841.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15434.06 Da        Isoelectric Point: 5.0350

>T20663 WP_010978835.1 NC_003106:816691-817092 [Sulfurisphaera tokodaii str. 7]
VEKAIIDTNVIIYDYVEDSEYHKKAEELLDSLNKWIIPAIVIHELVWFLKDMKLEDKINDVFAYVRNEKAEVICDSVNNI
VDSLEILIREKLPLADYKDMIILSHAIREKLPLVTFDKKLSKIAKKYGVSVVS

Download         Length: 402 bp

>T20663 NC_003106:816691-817092 [Sulfurisphaera tokodaii str. 7]
GTGGAGAAGGCAATAATTGATACTAACGTTATAATATACGACTACGTTGAGGACTCGGAATATCATAAAAAAGCGGAAGA
ACTTCTAGATTCGCTTAATAAATGGATAATTCCAGCAATTGTTATACATGAACTAGTATGGTTTCTAAAAGATATGAAAT
TAGAAGATAAGATTAATGATGTTTTTGCATATGTAAGGAATGAAAAAGCCGAGGTGATATGTGACAGTGTAAATAACATA
GTAGATTCCTTAGAAATATTAATTAGAGAAAAACTTCCTCTAGCCGATTATAAGGATATGATTATACTCTCCCATGCAAT
ACGCGAAAAATTACCTTTAGTTACTTTTGATAAAAAACTTTCAAAGATAGCAAAAAAGTATGGTGTATCTGTAGTAAGTT
AA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.84 Da        Isoelectric Point: 9.5338

>AT20663 WP_010978834.1 NC_003106:816489-816710 [Sulfurisphaera tokodaii str. 7]
MERVKVTRNYQITIPASIRNKINLKEGDILEVYLNGDEIVLRKVKSERPRIRLGKKLYPEEIEEAIERGEGNN

Download         Length: 222 bp

>AT20663 NC_003106:816489-816710 [Sulfurisphaera tokodaii str. 7]
ATGGAGAGGGTAAAAGTTACAAGAAACTATCAAATAACTATTCCTGCTTCTATAAGAAATAAAATAAATCTAAAAGAAGG
AGATATTCTAGAGGTCTATTTAAACGGTGATGAAATAGTATTAAGAAAGGTTAAAAGTGAAAGACCAAGAATAAGGCTTG
GTAAGAAATTATACCCAGAAGAGATTGAGGAGGCAATTGAACGTGGAGAAGGCAATAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A832T352

Antitoxin

Source ID Structure
AlphaFold DB A0A832TGZ2

References