Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2833822..2834441 Replicon chromosome
Accession NZ_CP077074
Organism Pseudomonas sessilinigenes strain CMR12a

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KSS89_RS13275 Protein ID WP_124346520.1
Coordinates 2834259..2834441 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KSS89_RS13270 Protein ID WP_124346519.1
Coordinates 2833822..2834223 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS89_RS13250 (KSS89_13250) 2830679..2831110 - 432 WP_124346515.1 carboxymuconolactone decarboxylase family protein -
KSS89_RS13255 (KSS89_13255) 2831138..2831758 - 621 WP_124346516.1 NAD(P)H-dependent oxidoreductase -
KSS89_RS13260 (KSS89_13260) 2831755..2832201 - 447 WP_124346517.1 GNAT family N-acetyltransferase -
KSS89_RS13265 (KSS89_13265) 2832289..2833692 + 1404 WP_124346518.1 PLP-dependent aminotransferase family protein -
KSS89_RS13270 (KSS89_13270) 2833822..2834223 - 402 WP_124346519.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KSS89_RS13275 (KSS89_13275) 2834259..2834441 - 183 WP_124346520.1 type II toxin-antitoxin system HicA family toxin Toxin
KSS89_RS13280 (KSS89_13280) 2834824..2835084 - 261 WP_124346521.1 DUF6429 family protein -
KSS89_RS13285 (KSS89_13285) 2835587..2835868 - 282 WP_124346522.1 hypothetical protein -
KSS89_RS13290 (KSS89_13290) 2836466..2839072 + 2607 WP_124346523.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6827.05 Da        Isoelectric Point: 11.6157

>T206629 WP_124346520.1 NZ_CP077074:c2834441-2834259 [Pseudomonas sessilinigenes]
VQSRQLIKELEAAGWILDRITGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLI

Download         Length: 183 bp

>T206629 NZ_CP102534:1141564-1141830 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTCACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14600.64 Da        Isoelectric Point: 5.1405

>AT206629 WP_124346519.1 NZ_CP077074:c2834223-2833822 [Pseudomonas sessilinigenes]
MQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFESAYSAAIEIAHVMLEELARAGQAIPLPSPTHKHRVNPDFAGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT206629 NZ_CP102534:1141337-1141567 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References