Detailed information of TA system TA206627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1169044..1169582
• Replicon: chromosome
• Accession: NZ_CP077074
• Organism: Pseudomonas sessilinigenes strain CMR12a

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6G6ZTT3
• Locus tag: KSS89_RS05240
• Protein ID: WP_068575728.1
• Coordinates: 1169304..1169582 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KSS89_RS05235
• Protein ID: WP_083236103.1
• Coordinates: 1169044..1169307 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSS89_RS05220 (KSS89_05220)	1165011..1167311	-	2301	WP_124345737.1	TonB-dependent siderophore receptor	-
KSS89_RS05225 (KSS89_05225)	1167520..1168200	+	681	WP_068575723.1	Fe2+-dependent dioxygenase	-
KSS89_RS05230 (KSS89_05230)	1168204..1168989	+	786	WP_124345738.1	tetratricopeptide repeat protein	-
KSS89_RS05235 (KSS89_05235)	1169044..1169307	+	264	WP_083236103.1	ribbon-helix-helix domain-containing protein	Antitoxin
KSS89_RS05240 (KSS89_05240)	1169304..1169582	+	279	WP_068575728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KSS89_RS05245 (KSS89_05245)	1169667..1170830	-	1164	WP_068575730.1	type III PLP-dependent enzyme	-
KSS89_RS05250 (KSS89_05250)	1171508..1172665	-	1158	WP_068575732.1	ABC transporter ATP-binding protein	-
KSS89_RS05255 (KSS89_05255)	1172662..1173330	-	669	WP_068575734.1	ABC transporter permease	-
KSS89_RS05260 (KSS89_05260)	1173343..1174236	-	894	WP_124345739.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10787.55 Da
• Isoelectric Point: 10.8284

>T206627 WP_068575728.1 NZ_CP077074:1169304-1169582 [Pseudomonas sessilinigenes]
MRQLKWTSKALSDLARLFEFLAQVNRSAAARTVQSLVRAPDALLSNPRLGEQLEEFKPKDVRRLLVGHYEVRYEIQGMVL
SILRIWHVREDR

Nucleotide

• Length: 279 bp

>T206627 NZ_CP102532:c1731396-1731133 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAAAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACTGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATGACGAATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9691.09 Da
• Isoelectric Point: 5.0878

>AT206627 WP_083236103.1 NZ_CP077074:1169044-1169307 [Pseudomonas sessilinigenes]
MPATKVLTAHIPLDLADKVDQLASRLERSRAWIVKQALVAWVDQEEERRRLTLEALADVDAGRVVDHQSVLAWAESLSGD
NPLPLPK

Nucleotide

• Length: 264 bp

>AT206627 NZ_CP102532:c1731647-1731393 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAGGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA

Structures

Toxin

• AlphaFold DB: A0A6G6ZTT3